Mouse eye gene microarrays for investigating ocular development and disease

Rafal Farjo, Jindan Yu, Mohammad I. Othman, Shigeo Yoshida, Sujata Sheth, Tom Glaser, Wolfgang Baehr, Anand Swaroop

研究成果: Contribution to journalArticle査読

39 被引用数 (Scopus)

抄録

Microarray technology can facilitate simultaneous expression analysis of thousands of genes and assist in delineating cellular pathways involved in development or disease pathogenesis. Since public databases and commercial cDNA microarrays have an under-representation of eye-expressed genes, we generated over 3000 expressed sequence tags from three unamplified mouse eye/retina cDNA libraries. These eye-expressed genes were used to produce cDNA microarrays. Methodology for printing of slides, hybridization, scanning and data analysis has been optimized. The I-gene microarrays will be useful for establishing expression profiles of the mouse eye/retina and provide a resource for defining molecular pathways involved in development, aging and disease.

本文言語英語
ページ(範囲)463-470
ページ数8
ジャーナルVision Research
42
4
DOI
出版ステータス出版済み - 2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系

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