Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3

Keisuke Sanematsu, Keiko Yasumatsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Gurmarin (Gur) is a peptide that selectively inhibits responses of the chorda tympani (CT) nerve to sweet compounds in rodents. In mice, the sweet-suppressing effect of Gur differs among strains. The inhibitory effect of Gur is clearly observed in C57BL/6 mice, but only slightly, if at all, in BALB/c mice. These two mouse strains possess different alleles of the sweet receptor gene, Sac(Tas1r3) (taster genotype for C57BL/6 and non-taster genotype for BALB/c mice), suggesting that polymorphisms in the gene may account for differential sensitivity to Gur. To investigate this possibility, we examined the effect of Gur in another Tas1r3 non-taster strain, 129X1/Sv mice. The results indicated that unlike non-taster BALB/c mice but similar to taster C57BL/6 mice, 129X1/Sv mice exhibited significant inhibition of CT responses to various sweet compounds by Gur. This suggests that the mouse strain difference in the Gur inhibition of sweet responses of the CT nerve may not be associated with polymorphisms of Tas1r3.

本文言語英語
ページ(範囲)491-496
ページ数6
ジャーナルChemical Senses
30
6
DOI
出版ステータス出版済み - 7 2005

All Science Journal Classification (ASJC) codes

  • 生理学
  • 感覚系
  • 生理学(医学)
  • 行動神経科学

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