Mouse T cell antigen receptor

Structure and organization of constant and joining gene segments encoding the β polypeptide

Marie Malissen, Karyl Minard, Shelley Mjolsness, Mitchell Kronenberg, Joan Goverman, Tim Hunkapiller, Michael B. Prystowsky, Yasunobu Yoshikai, Frank Fitch, Tak W. Mak, Leroy Hood

    研究成果: ジャーナルへの寄稿記事

    299 引用 (Scopus)

    抄録

    The germ-line joining (J) gene segments and constant (C) genes encoding the β chain of the mouse T cell antigen receptor have been isolated on a single cosmid clone. There are two constant genes, Cβ1 and Cβ2, each associated with a cluster of Jβ gene segments. The nucleotide sequences of the Cβ2 gene and of the Jβ2 cluster gene segments have been determined. The coding sequence of the Cβ2 gene is very similar to the sequence of a cDNA clone encoded by the Cβ1 gene. The Cβ2 gene has four exons; exon-intron structure does not obviously correspond to the functional domains of the protein. The Jβ2 gene segment cluster contains six functional J gene segments. We have isolated specific probes for the Cβ1, Cβ2, Jβ1, and Jβ2 regions to examine DNA rearrangements in T lymphocytes. DNA rearrangements can occur in both Jβ gene segment clusters, and both Cβ genes appear functional.

    元の言語英語
    ページ(範囲)1101-1110
    ページ数10
    ジャーナルCell
    37
    発行部数3
    DOI
    出版物ステータス出版済み - 1 1 1984

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    Gene encoding
    T-Cell Antigen Receptor
    Joining
    Genes
    Peptides
    Multigene Family
    Gene Rearrangement
    Exons
    Clone Cells
    Cosmids
    Germ Cells
    Introns
    T-cells
    DNA
    Complementary DNA
    T-Lymphocytes
    Nucleotides

    All Science Journal Classification (ASJC) codes

    • Biochemistry, Genetics and Molecular Biology(all)

    これを引用

    Malissen, M., Minard, K., Mjolsness, S., Kronenberg, M., Goverman, J., Hunkapiller, T., ... Hood, L. (1984). Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide. Cell, 37(3), 1101-1110. https://doi.org/10.1016/0092-8674(84)90444-6

    Mouse T cell antigen receptor : Structure and organization of constant and joining gene segments encoding the β polypeptide. / Malissen, Marie; Minard, Karyl; Mjolsness, Shelley; Kronenberg, Mitchell; Goverman, Joan; Hunkapiller, Tim; Prystowsky, Michael B.; Yoshikai, Yasunobu; Fitch, Frank; Mak, Tak W.; Hood, Leroy.

    :: Cell, 巻 37, 番号 3, 01.01.1984, p. 1101-1110.

    研究成果: ジャーナルへの寄稿記事

    Malissen, M, Minard, K, Mjolsness, S, Kronenberg, M, Goverman, J, Hunkapiller, T, Prystowsky, MB, Yoshikai, Y, Fitch, F, Mak, TW & Hood, L 1984, 'Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide', Cell, 巻. 37, 番号 3, pp. 1101-1110. https://doi.org/10.1016/0092-8674(84)90444-6
    Malissen M, Minard K, Mjolsness S, Kronenberg M, Goverman J, Hunkapiller T その他. Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide. Cell. 1984 1 1;37(3):1101-1110. https://doi.org/10.1016/0092-8674(84)90444-6
    Malissen, Marie ; Minard, Karyl ; Mjolsness, Shelley ; Kronenberg, Mitchell ; Goverman, Joan ; Hunkapiller, Tim ; Prystowsky, Michael B. ; Yoshikai, Yasunobu ; Fitch, Frank ; Mak, Tak W. ; Hood, Leroy. / Mouse T cell antigen receptor : Structure and organization of constant and joining gene segments encoding the β polypeptide. :: Cell. 1984 ; 巻 37, 番号 3. pp. 1101-1110.
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    abstract = "The germ-line joining (J) gene segments and constant (C) genes encoding the β chain of the mouse T cell antigen receptor have been isolated on a single cosmid clone. There are two constant genes, Cβ1 and Cβ2, each associated with a cluster of Jβ gene segments. The nucleotide sequences of the Cβ2 gene and of the Jβ2 cluster gene segments have been determined. The coding sequence of the Cβ2 gene is very similar to the sequence of a cDNA clone encoded by the Cβ1 gene. The Cβ2 gene has four exons; exon-intron structure does not obviously correspond to the functional domains of the protein. The Jβ2 gene segment cluster contains six functional J gene segments. We have isolated specific probes for the Cβ1, Cβ2, Jβ1, and Jβ2 regions to examine DNA rearrangements in T lymphocytes. DNA rearrangements can occur in both Jβ gene segment clusters, and both Cβ genes appear functional.",
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    AU - Goverman, Joan

    AU - Hunkapiller, Tim

    AU - Prystowsky, Michael B.

    AU - Yoshikai, Yasunobu

    AU - Fitch, Frank

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