MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity

Hiroshi Honda, K. Kaneko, Y. Kanazawa, T. Hayashi, T. Fukuya, T. Matsumata, T. Maeda, K. Masuda

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

Background: To elucidate the metallic factors contributing to the signal intensities of hepatocellular carcinoma (HCC) on T1-weighted magnetic resonance (MR) images and to determine whether or not changes in signal intensity contribute to the diagnosis of histological grading of HCC. Methods: In 35 patients immediately after surgery, the quantities of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) were determined in HCCs and the surrounding hepatic parenchyma. The correlations among these findings, the histopathological findings, and the signal intensities of T1-weighted MR images were evaluated. Results: Among the 35 HCCs, 12 (34%) were of high intensity, 14 (40%) were isointense, and 9 (26%) were of low intensity on T1- weighted images versus the surrounding hepatic parenchyma. The paramagnetic ions, which contributed to the signal intensity patterns, were assumed to be Cu in HCCs (30.5 ± 52.9 μg/g ww), and Fe in the livers (106.2 ± 86.8 μg/g ww) and HCCs (87.7 ± 49.1 μg/g ww). In 12 HCCs with high intensity, one was grade I, eight were grade II, and three were grade III according to Edmondson-Steiner's histopathological classification. Conclusions: Signal intensity and signal intensity patterns alone cannot be signs of low-grade malignancy because of the Fe in livers and in HCCs.

元の言語英語
ページ(範囲)60-66
ページ数7
ジャーナルAbdominal imaging
22
発行部数1
DOI
出版物ステータス出版済み - 1 22 1997

Fingerprint

Hepatocellular Carcinoma
Magnetic Resonance Imaging
Liver
Magnetic Resonance Spectroscopy
Manganese
Copper
Iron
Ions
Lipids
Water
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

これを引用

Honda, H., Kaneko, K., Kanazawa, Y., Hayashi, T., Fukuya, T., Matsumata, T., ... Masuda, K. (1997). MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity. Abdominal imaging, 22(1), 60-66. https://doi.org/10.1007/s002619900141

MR imaging of hepatocellular carcinomas : Effect of Cu and Fe contents on signal intensity. / Honda, Hiroshi; Kaneko, K.; Kanazawa, Y.; Hayashi, T.; Fukuya, T.; Matsumata, T.; Maeda, T.; Masuda, K.

:: Abdominal imaging, 巻 22, 番号 1, 22.01.1997, p. 60-66.

研究成果: ジャーナルへの寄稿記事

Honda, H, Kaneko, K, Kanazawa, Y, Hayashi, T, Fukuya, T, Matsumata, T, Maeda, T & Masuda, K 1997, 'MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity', Abdominal imaging, 巻. 22, 番号 1, pp. 60-66. https://doi.org/10.1007/s002619900141
Honda H, Kaneko K, Kanazawa Y, Hayashi T, Fukuya T, Matsumata T その他. MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity. Abdominal imaging. 1997 1 22;22(1):60-66. https://doi.org/10.1007/s002619900141
Honda, Hiroshi ; Kaneko, K. ; Kanazawa, Y. ; Hayashi, T. ; Fukuya, T. ; Matsumata, T. ; Maeda, T. ; Masuda, K. / MR imaging of hepatocellular carcinomas : Effect of Cu and Fe contents on signal intensity. :: Abdominal imaging. 1997 ; 巻 22, 番号 1. pp. 60-66.
@article{1cd0e9cc302f420bba3edafee22b98d4,
title = "MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity",
abstract = "Background: To elucidate the metallic factors contributing to the signal intensities of hepatocellular carcinoma (HCC) on T1-weighted magnetic resonance (MR) images and to determine whether or not changes in signal intensity contribute to the diagnosis of histological grading of HCC. Methods: In 35 patients immediately after surgery, the quantities of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) were determined in HCCs and the surrounding hepatic parenchyma. The correlations among these findings, the histopathological findings, and the signal intensities of T1-weighted MR images were evaluated. Results: Among the 35 HCCs, 12 (34{\%}) were of high intensity, 14 (40{\%}) were isointense, and 9 (26{\%}) were of low intensity on T1- weighted images versus the surrounding hepatic parenchyma. The paramagnetic ions, which contributed to the signal intensity patterns, were assumed to be Cu in HCCs (30.5 ± 52.9 μg/g ww), and Fe in the livers (106.2 ± 86.8 μg/g ww) and HCCs (87.7 ± 49.1 μg/g ww). In 12 HCCs with high intensity, one was grade I, eight were grade II, and three were grade III according to Edmondson-Steiner's histopathological classification. Conclusions: Signal intensity and signal intensity patterns alone cannot be signs of low-grade malignancy because of the Fe in livers and in HCCs.",
author = "Hiroshi Honda and K. Kaneko and Y. Kanazawa and T. Hayashi and T. Fukuya and T. Matsumata and T. Maeda and K. Masuda",
year = "1997",
month = "1",
day = "22",
doi = "10.1007/s002619900141",
language = "English",
volume = "22",
pages = "60--66",
journal = "Abdominal Radiology",
issn = "2366-004X",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - MR imaging of hepatocellular carcinomas

T2 - Effect of Cu and Fe contents on signal intensity

AU - Honda, Hiroshi

AU - Kaneko, K.

AU - Kanazawa, Y.

AU - Hayashi, T.

AU - Fukuya, T.

AU - Matsumata, T.

AU - Maeda, T.

AU - Masuda, K.

PY - 1997/1/22

Y1 - 1997/1/22

N2 - Background: To elucidate the metallic factors contributing to the signal intensities of hepatocellular carcinoma (HCC) on T1-weighted magnetic resonance (MR) images and to determine whether or not changes in signal intensity contribute to the diagnosis of histological grading of HCC. Methods: In 35 patients immediately after surgery, the quantities of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) were determined in HCCs and the surrounding hepatic parenchyma. The correlations among these findings, the histopathological findings, and the signal intensities of T1-weighted MR images were evaluated. Results: Among the 35 HCCs, 12 (34%) were of high intensity, 14 (40%) were isointense, and 9 (26%) were of low intensity on T1- weighted images versus the surrounding hepatic parenchyma. The paramagnetic ions, which contributed to the signal intensity patterns, were assumed to be Cu in HCCs (30.5 ± 52.9 μg/g ww), and Fe in the livers (106.2 ± 86.8 μg/g ww) and HCCs (87.7 ± 49.1 μg/g ww). In 12 HCCs with high intensity, one was grade I, eight were grade II, and three were grade III according to Edmondson-Steiner's histopathological classification. Conclusions: Signal intensity and signal intensity patterns alone cannot be signs of low-grade malignancy because of the Fe in livers and in HCCs.

AB - Background: To elucidate the metallic factors contributing to the signal intensities of hepatocellular carcinoma (HCC) on T1-weighted magnetic resonance (MR) images and to determine whether or not changes in signal intensity contribute to the diagnosis of histological grading of HCC. Methods: In 35 patients immediately after surgery, the quantities of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) were determined in HCCs and the surrounding hepatic parenchyma. The correlations among these findings, the histopathological findings, and the signal intensities of T1-weighted MR images were evaluated. Results: Among the 35 HCCs, 12 (34%) were of high intensity, 14 (40%) were isointense, and 9 (26%) were of low intensity on T1- weighted images versus the surrounding hepatic parenchyma. The paramagnetic ions, which contributed to the signal intensity patterns, were assumed to be Cu in HCCs (30.5 ± 52.9 μg/g ww), and Fe in the livers (106.2 ± 86.8 μg/g ww) and HCCs (87.7 ± 49.1 μg/g ww). In 12 HCCs with high intensity, one was grade I, eight were grade II, and three were grade III according to Edmondson-Steiner's histopathological classification. Conclusions: Signal intensity and signal intensity patterns alone cannot be signs of low-grade malignancy because of the Fe in livers and in HCCs.

UR - http://www.scopus.com/inward/record.url?scp=0031014981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031014981&partnerID=8YFLogxK

U2 - 10.1007/s002619900141

DO - 10.1007/s002619900141

M3 - Article

C2 - 9000358

AN - SCOPUS:0031014981

VL - 22

SP - 60

EP - 66

JO - Abdominal Radiology

JF - Abdominal Radiology

SN - 2366-004X

IS - 1

ER -