MR relative cerebral blood flow mapping of Alzheimer disease: Correlation with Tc-99m HMPAO SPECT

Takashi Yoshiura, Futoshi Mihara, Yasuhiro Kuwabara, Koji Ogomori, Koichiro Kaneko, Atsuo Tanaka, Masayuki Sasaki, Makoto Nakagawa, Hirofumi Koga, Takeharu Yamanaka, Kouji Masuda

研究成果: Contribution to journalArticle査読

17 被引用数 (Scopus)


Rationale and Objectives. To evaluate the value of magnetic resonance (MR) perfusion imaging for diagnosis of Alzheimer disease (AD), the authors compared relative cerebral blood flow (CBF) maps obtained with MR perfusion imaging and technetium-99m hexamethyl-propyleneamine oxime (HMPAO) single photon emission computed tomography (SPECT) in patients with AD. Materials and Methods. Eight patients with AD were studied with MR perfusion imaging and HMPAO SPECT. The relative CBF maps from the two techniques were spatially coregistered, and relative CBF values in 13 cerebral gray matter regions (total, 26 regions of interest) were compared with regression analysis. To evaluate the degree of deviation of each brain region from the regression line, a P value for the residual was calculated for each region. Results. A significant overall correlation was seen between the relative CBF values produced by the two techniques (r = .68, P < .0001). Smaller P values for the residuals were obtained in the anterior cingulate cortex (P = .05) and posterior cingulate cortex (P < .001), indicating larger deviations in these regions. When data from these two regions were eliminated, the correlation coefficient rose to 0.80 (P < .0001). Conclusion. Despite fairly large discrepancies in the anterior and posterior cingulate cortices, the relative CBF map obtained with MR imaging is generally in close agreement with the HMPAO SPECT map, suggesting that MR perfusion imaging can provide clinically useful information regarding CBF abnormalities in patients with AD.

ジャーナルAcademic Radiology
出版ステータス出版済み - 12 1 2002

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング


「MR relative cerebral blood flow mapping of Alzheimer disease: Correlation with Tc-99m HMPAO SPECT」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。