Mucosal proinflammatory cytokine and chemokine expression of gastroduodenal lesions in Crohn's disease

T. Moriyama, T. Matsumoto, Y. Jo, S. Yada, M. Hirahashi, T. Yao, M. Iida

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Background: The stomach and the duodenum are frequent sites of involvement by diminutive lesions in Crohn's disease (CD). Aim: To assess mucosal proinflammatory cytokines and chemokines in gastroduodenal lesions of CD. Methods: 13C-Urea breath test and upper endoscopy were performed in 29 CD patients and seven control subjects, and biopsy specimens were obtained from the gastric cardia and the duodenum. Histology and mucosal levels of IL-1β, IL-8/CXCL8 and RANTES/CCL5 were assessed and compared according to the presence of gastric cardial lesion [bamboo joint-like appearance (BJA)] and duodenal lesion (notched appearance, aphthous erosion and polypoid lesion). In 11 CD patients, these procedures were repeatedly performed after administration of famotidine. Results: H. pylori was less frequently positive in CD patients than in controls (10% vs. 71%, P = 0.003). Prevalence of cardial and duodenal lesion was significantly higher in CD than in controls (59% vs. 0%, P = 0.008 for gastric lesion; 45% vs. 0%, P = 0.034 for duodenal lesion). There were no differences in IL-1β, IL-8 and RANTES between CD and controls. Duodenal mucosal IL-1β and IL-8 were significantly higher in positive duodenal lesion than in negative duodenal lesion. However, there were no such differences with respect to cardial lesions. Endoscopic findings remained unchanged after administration of famotidine, while there was a trend towards decreases in IL-1β and IL-8 in the gastric cardia. Conclusions: The pathogenesis of diminutive lesions of CD may be different between the stomach and the duodenum. Famotidine may not have a therapeutic effect on duodenal lesion in CD.

本文言語英語
ページ(範囲)85-91
ページ数7
ジャーナルAlimentary Pharmacology and Therapeutics, Supplement
21
2
DOI
出版ステータス出版済み - 6月 2005

!!!All Science Journal Classification (ASJC) codes

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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