Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function

Keita Fukaura, Eikichi Ihara, Haruei Ogino, Yoichiro Iboshi, Kazumasa Muta, Bai Xiaopeng, Shohei Hamada, Yoshitaka Hata, tsutomu iwasa, Akira Aso, Kazuhiko Nakamura, Yoshihiro Ogawa

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Background and Aim: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. Methods: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. Results: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1). The expression of tumor necrosis factor (TNF)-α in the esophagogastric junction (EGJ) was significantly higher in EGJOO (14.6, 14.0-15.8, n = 10) than in normal esophageal motility (13.3, 12.8-14.1, n = 25); however, there was no difference in the expression of TNF-α between achalasia (13.4, 13.0-14.1, n = 10) and normal esophageal motility (13.3, 12.8-14.1, n = 25). EGJOO was discriminated from achalasia/normal by a linear discriminant analysis (AUC = 0.917). A multivariable regression analysis revealed that interleukin (IL)-13 and IL-23A were predictive of the distal contractile integral, whereas TNF-α and IL-6 were predictive of the basal EGJ pressure. Conclusions: The esophageal motility was associated with mucosally expressed cytokines in humans; these cytokines could be useful targets for the diagnosis and treatment of EMDs.

元の言語英語
ページ(範囲)95-103
ページ数9
ジャーナルDigestion
98
発行部数2
DOI
出版物ステータス出版済み - 8 1 2018

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Esophagogastric Junction
Esophageal Achalasia
Esophageal Motility Disorders
Cytokines
Tumor Necrosis Factor-alpha
Diffuse Esophageal Spasm
Gastrointestinal Motility
Interleukin-13
Interleukins
Manometry
Discriminant Analysis
Esophagus
Area Under Curve
Interleukin-6
Regression Analysis
Pressure
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function. / Fukaura, Keita; Ihara, Eikichi; Ogino, Haruei; Iboshi, Yoichiro; Muta, Kazumasa; Xiaopeng, Bai; Hamada, Shohei; Hata, Yoshitaka; iwasa, tsutomu; Aso, Akira; Nakamura, Kazuhiko; Ogawa, Yoshihiro.

:: Digestion, 巻 98, 番号 2, 01.08.2018, p. 95-103.

研究成果: ジャーナルへの寄稿記事

Fukaura, K, Ihara, E, Ogino, H, Iboshi, Y, Muta, K, Xiaopeng, B, Hamada, S, Hata, Y, iwasa, T, Aso, A, Nakamura, K & Ogawa, Y 2018, 'Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function', Digestion, 巻. 98, 番号 2, pp. 95-103. https://doi.org/10.1159/000487708
Fukaura, Keita ; Ihara, Eikichi ; Ogino, Haruei ; Iboshi, Yoichiro ; Muta, Kazumasa ; Xiaopeng, Bai ; Hamada, Shohei ; Hata, Yoshitaka ; iwasa, tsutomu ; Aso, Akira ; Nakamura, Kazuhiko ; Ogawa, Yoshihiro. / Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function. :: Digestion. 2018 ; 巻 98, 番号 2. pp. 95-103.
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abstract = "Background and Aim: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. Methods: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. Results: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1). The expression of tumor necrosis factor (TNF)-α in the esophagogastric junction (EGJ) was significantly higher in EGJOO (14.6, 14.0-15.8, n = 10) than in normal esophageal motility (13.3, 12.8-14.1, n = 25); however, there was no difference in the expression of TNF-α between achalasia (13.4, 13.0-14.1, n = 10) and normal esophageal motility (13.3, 12.8-14.1, n = 25). EGJOO was discriminated from achalasia/normal by a linear discriminant analysis (AUC = 0.917). A multivariable regression analysis revealed that interleukin (IL)-13 and IL-23A were predictive of the distal contractile integral, whereas TNF-α and IL-6 were predictive of the basal EGJ pressure. Conclusions: The esophageal motility was associated with mucosally expressed cytokines in humans; these cytokines could be useful targets for the diagnosis and treatment of EMDs.",
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T1 - Mucosally Expressed Cytokines are Associated with the Esophageal Motility Function

AU - Fukaura, Keita

AU - Ihara, Eikichi

AU - Ogino, Haruei

AU - Iboshi, Yoichiro

AU - Muta, Kazumasa

AU - Xiaopeng, Bai

AU - Hamada, Shohei

AU - Hata, Yoshitaka

AU - iwasa, tsutomu

AU - Aso, Akira

AU - Nakamura, Kazuhiko

AU - Ogawa, Yoshihiro

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background and Aim: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. Methods: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. Results: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1). The expression of tumor necrosis factor (TNF)-α in the esophagogastric junction (EGJ) was significantly higher in EGJOO (14.6, 14.0-15.8, n = 10) than in normal esophageal motility (13.3, 12.8-14.1, n = 25); however, there was no difference in the expression of TNF-α between achalasia (13.4, 13.0-14.1, n = 10) and normal esophageal motility (13.3, 12.8-14.1, n = 25). EGJOO was discriminated from achalasia/normal by a linear discriminant analysis (AUC = 0.917). A multivariable regression analysis revealed that interleukin (IL)-13 and IL-23A were predictive of the distal contractile integral, whereas TNF-α and IL-6 were predictive of the basal EGJ pressure. Conclusions: The esophageal motility was associated with mucosally expressed cytokines in humans; these cytokines could be useful targets for the diagnosis and treatment of EMDs.

AB - Background and Aim: Although basic research has shown that certain cytokines affect gastrointestinal motility, the clinical evidence is lacking. The objective of this study was to explore the association between mucosally expressed cytokines and the esophageal motility function in humans. Methods: We enrolled a total of 57 patients with suspected esophageal motility disorders (EMDs) who underwent high-resolution manometry. Results: The diagnoses of the patients were as follows: normal esophageal motility (n = 25), ineffective esophageal motility (n = 5), esophagogastric junction outflow obstruction (EGJOO; n = 10), distal esophageal spasm (n = 5), achalasia (n = 10), absent contractility (n = 1), and jackhammer esophagus (n = 1). The expression of tumor necrosis factor (TNF)-α in the esophagogastric junction (EGJ) was significantly higher in EGJOO (14.6, 14.0-15.8, n = 10) than in normal esophageal motility (13.3, 12.8-14.1, n = 25); however, there was no difference in the expression of TNF-α between achalasia (13.4, 13.0-14.1, n = 10) and normal esophageal motility (13.3, 12.8-14.1, n = 25). EGJOO was discriminated from achalasia/normal by a linear discriminant analysis (AUC = 0.917). A multivariable regression analysis revealed that interleukin (IL)-13 and IL-23A were predictive of the distal contractile integral, whereas TNF-α and IL-6 were predictive of the basal EGJ pressure. Conclusions: The esophageal motility was associated with mucosally expressed cytokines in humans; these cytokines could be useful targets for the diagnosis and treatment of EMDs.

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U2 - 10.1159/000487708

DO - 10.1159/000487708

M3 - Article

VL - 98

SP - 95

EP - 103

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 2

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