Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition

N. Shikata, Y. Maki, Y. Noguchi, M. Mori, Taizo Hanai, M. Takahashi, Masahiro Okamoto

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

抄録

The concentrations of free amino acids in plasma change coordinately and their profiles show distinctive features in various physiological conditions; however, their behavior can not always be explained by the conventional flow-based metabolic pathway network. In this study, we have revealed the interrelatedness of the plasma amino acids and inferred their network structure with threshold-test analysis and multilevel-digraph analysis methods using the plasma samples of rats which are fed diet deficient in single essential amino acid. In the inferred network, we could draw some interesting interrelations between plasma amino acids as follows: 1) Lysine is located at the top control level and has effects on almost all of the other plasma amino acids. 2) Threonine plays a role in a hub in the network, which has direct links to the most number of other amino acids. 3) Threonine and methionine are interrelated to each other and form a loop structure.

元の言語英語
ページ(範囲)113-121
ページ数9
ジャーナルAmino Acids
33
発行部数1
DOI
出版物ステータス出版済み - 7 1 2007

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Essential Amino Acids
Metabolism
Plasmas
Amino Acids
Threonine
Multilevel Analysis
Level control
Nutrition
Metabolic Networks and Pathways
Methionine
Lysine
Rats
Diet

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

これを引用

Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition. / Shikata, N.; Maki, Y.; Noguchi, Y.; Mori, M.; Hanai, Taizo; Takahashi, M.; Okamoto, Masahiro.

:: Amino Acids, 巻 33, 番号 1, 01.07.2007, p. 113-121.

研究成果: ジャーナルへの寄稿記事

Shikata, N. ; Maki, Y. ; Noguchi, Y. ; Mori, M. ; Hanai, Taizo ; Takahashi, M. ; Okamoto, Masahiro. / Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition. :: Amino Acids. 2007 ; 巻 33, 番号 1. pp. 113-121.
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AU - Takahashi, M.

AU - Okamoto, Masahiro

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