Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation

Nozomi Abe, Hiroki Yasudo, Reiji Fukano, Tamaki Nakamura, Seigo Okada, Hiroyuki Wakiguchi, Fumiko Okazaki, Komei Shirabe, Shoichi Toda, Reiko Okamoto, Kazunobu Ouchi, Shoichi Ohga, Shunji Hasegawa

研究成果: ジャーナルへの寄稿記事

抄録

Background: Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three-year period. Methods: Hospitalized asthmatic children with attack aged 6 months-17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription-polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results: Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV-associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV-D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion: Our three-year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV-associated asthma development and exacerbation. Multiple-year monitoring allowed us to comprehend the profile of virus- and/or mycoplasma-induced asthma exacerbation.

元の言語英語
ジャーナルPediatric Allergy and Immunology
DOI
出版物ステータス受理済み/印刷中 - 1 1 2019

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Hospitalized Child
Rhinovirus
Asthma
Viruses
Mycoplasma pneumoniae
Respiratory Syncytial Viruses
Enterovirus
Mycoplasma Infections
Paramyxoviridae Infections
Respiratory Syncytial Virus Infections
Mycoplasma
Virus Diseases
Infection
Respiratory Tract Infections
Allergens
Reverse Transcription
Mucous Membrane
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

これを引用

Abe, N., Yasudo, H., Fukano, R., Nakamura, T., Okada, S., Wakiguchi, H., ... Hasegawa, S. (受理済み/印刷中). Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation. Pediatric Allergy and Immunology. https://doi.org/10.1111/pai.13102

Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation. / Abe, Nozomi; Yasudo, Hiroki; Fukano, Reiji; Nakamura, Tamaki; Okada, Seigo; Wakiguchi, Hiroyuki; Okazaki, Fumiko; Shirabe, Komei; Toda, Shoichi; Okamoto, Reiko; Ouchi, Kazunobu; Ohga, Shoichi; Hasegawa, Shunji.

:: Pediatric Allergy and Immunology, 01.01.2019.

研究成果: ジャーナルへの寄稿記事

Abe, N, Yasudo, H, Fukano, R, Nakamura, T, Okada, S, Wakiguchi, H, Okazaki, F, Shirabe, K, Toda, S, Okamoto, R, Ouchi, K, Ohga, S & Hasegawa, S 2019, 'Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation', Pediatric Allergy and Immunology. https://doi.org/10.1111/pai.13102
Abe, Nozomi ; Yasudo, Hiroki ; Fukano, Reiji ; Nakamura, Tamaki ; Okada, Seigo ; Wakiguchi, Hiroyuki ; Okazaki, Fumiko ; Shirabe, Komei ; Toda, Shoichi ; Okamoto, Reiko ; Ouchi, Kazunobu ; Ohga, Shoichi ; Hasegawa, Shunji. / Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation. :: Pediatric Allergy and Immunology. 2019.
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title = "Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation",
abstract = "Background: Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three-year period. Methods: Hospitalized asthmatic children with attack aged 6 months-17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription-polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results: Viruses and/or Mycoplasma pneumoniae were detected in 75{\%} of the participants. Rhinovirus (48{\%}) was the most commonly detected virus in the participants with single infection, followed by RSV (6{\%}). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV-associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV-D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion: Our three-year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV-associated asthma development and exacerbation. Multiple-year monitoring allowed us to comprehend the profile of virus- and/or mycoplasma-induced asthma exacerbation.",
author = "Nozomi Abe and Hiroki Yasudo and Reiji Fukano and Tamaki Nakamura and Seigo Okada and Hiroyuki Wakiguchi and Fumiko Okazaki and Komei Shirabe and Shoichi Toda and Reiko Okamoto and Kazunobu Ouchi and Shoichi Ohga and Shunji Hasegawa",
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T1 - Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation

AU - Abe, Nozomi

AU - Yasudo, Hiroki

AU - Fukano, Reiji

AU - Nakamura, Tamaki

AU - Okada, Seigo

AU - Wakiguchi, Hiroyuki

AU - Okazaki, Fumiko

AU - Shirabe, Komei

AU - Toda, Shoichi

AU - Okamoto, Reiko

AU - Ouchi, Kazunobu

AU - Ohga, Shoichi

AU - Hasegawa, Shunji

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three-year period. Methods: Hospitalized asthmatic children with attack aged 6 months-17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription-polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results: Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV-associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV-D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion: Our three-year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV-associated asthma development and exacerbation. Multiple-year monitoring allowed us to comprehend the profile of virus- and/or mycoplasma-induced asthma exacerbation.

AB - Background: Respiratory viral and mycoplasma infections are associated with childhood asthma exacerbations. Here, we explored epidemiologic profile of causative pathogens and possible factors for exacerbation in a single center over a three-year period. Methods: Hospitalized asthmatic children with attack aged 6 months-17 years were recruited between 2012 and 2015 (n = 216). Nasopharyngeal mucosa cell samples were collected from the participants and examined by reverse transcription-polymerase chain reaction to detect rhinovirus (RV), respiratory syncytial virus (RSV), enterovirus (EV), parainfluenza virus (PIV), Mycoplasma pneumoniae, and others. Clinical features, laboratory data, asthma exacerbation intensity, and asthma severity were compared among participants. Epidemiologic profile of causative pathogens and possible factors for exacerbation were explored. Results: Viruses and/or Mycoplasma pneumoniae were detected in 75% of the participants. Rhinovirus (48%) was the most commonly detected virus in the participants with single infection, followed by RSV (6%). The median age at admission in the RV group was significantly higher than that in the RSV group. Insufficient asthma control and allergen sensitization were significantly related to RV-associated asthma exacerbation. There was no seasonality of pathogen types associated with asthma exacerbation although a sporadic prevalence of EV-D68 was observehinovirud. Rhinovirus were repeatedly detected in multiple admission cases. Conclusion: Our three-year analysis revealed that patients with RV infection were significantly prone to repeated RV infection in the subsequent exacerbation and good asthma control could prevent RV-associated asthma development and exacerbation. Multiple-year monitoring allowed us to comprehend the profile of virus- and/or mycoplasma-induced asthma exacerbation.

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U2 - 10.1111/pai.13102

DO - 10.1111/pai.13102

M3 - Article

C2 - 31251831

AN - SCOPUS:85070667146

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

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