MULTIFUNCTIONAL HYDROLYTIC CATALYSES - 9. HYDROLYSIS OF p-NITROPHENYL ACETATE BY BIFUNCTIONAL POLYMER CATALYSTS CONTAINING ZWITTERIONIC (HYDROXAMATE) NUCLEOPHILES.

Yoshio Okahata, Toyoki Kunitake

研究成果: ジャーナルへの寄稿記事

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In the reported experiments, the hydrolysis of p-nitrophenyl acetate by bifunctional polymer catalysts was studied in 28. 9% EtOH-H//2O at 30 degree C. Partial (ca. 10 mole%) quaternization of poly(4-vinylpyridine) and poly(1-vinyl-2-ethylimidazole) with benzyl N-benzyl chloroacetohydroxamate and the subsequent removal of the benzyl group produced water-soluble polymers containing zwitterionic hydroxamate groups and free pyridine (or imidazole) groups. The zwitterionic hydroxamate was a nucleophile more than 10 times as effective as simple hydroxamate anions, and the acetyl hydroxamate intermediate was efficiently hydrolyzed by the intrapolymeric pyridine (or imidazole) group. Thus, the catalytic efficiency of these bifunctional polymers was much better than monofunctional polymers which contain either hydroxamate or imidazole, and amounted to 10-20% of that of alpha -chymotrypsin under a comparable condition.

元の言語英語
ページ(範囲)2571-2586
ページ数16
ジャーナルJ Polym Sci Polym Chem Ed
15
発行部数11
出版物ステータス出版済み - 1 1 1977
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

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