Multifunctional hydrolytic catalysis. II. Hydrolysis of p-nitrophenyl acetate by a polymer catalyst which contains hydroxamate and imidazole functions

Toyoki Kunitake, Yoshio Okahata

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

A water-soluble polymer catalyst was prepared by radical polymerization of a protected hydroxamate monomer, 1-methyl-2-vinylimidazole and acrylamide, and by the subsequent NH2NH2 treatment of the polymer. The hydrolysis of p-nitrophenyl acetate by the bifunctional copolymer obeyed typical burst kinetics: rapid accumulation of acetyl hydroxamate group and its slow decomposition. The acetylation rate of the hydroxamate group was rather close to that of a polymer which does not contain the imidazole unit. However, the deacylation was markedly accelerated by the presence of the imidazole unit, and the difference in rate constants amounted to 60- to 80-fold at pH 8-9. These results indicate that the overall catalytic efficiency of the bifunctional polymer is enhanced due to the complementary action of the imidazole and hydroxamate functions.

本文言語英語
ページ(範囲)136-148
ページ数13
ジャーナルBioorganic Chemistry
4
2
DOI
出版ステータス出版済み - 6月 1975

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 創薬
  • 有機化学

フィンガープリント

「Multifunctional hydrolytic catalysis. II. Hydrolysis of p-nitrophenyl acetate by a polymer catalyst which contains hydroxamate and imidazole functions」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル