Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8

Nobuharu Fujii, Kazuma Ikeda, Naoto Takahashi, Kensuke Kojima, Yoshimi Kobayashi, Atsuko Ashiba, Katsuto Takenaka, Shunnichi Fukuda, Katsuji Shinagawa, Fumihiko Ishimaru, Kenji Niiya, Ikuo Miura, Mitsune Tanimoto, Mine Harada

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.

本文言語英語
ページ(範囲)716-719
ページ数4
ジャーナルBritish Journal of Haematology
119
3
DOI
出版ステータス出版済み - 2002

All Science Journal Classification (ASJC) codes

  • 血液学

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