Multiple autoimmune haemopoietic disorders and insidious clonal proliferation of large granular lymphocytes

Koichi Akashi, Tsunefumi Shibuya, Shuichi Taniguchi, Shin Hayashi, Hiromi Iwasaki, Takanori Teshima, Yasushi Takamatsu, Hisashi Gondo, Takashi Okamura, Mine Harada, Yoshiyuki Niho

研究成果: ジャーナルへの寄稿学術誌査読

31 被引用数 (Scopus)

抄録

We report a patient with clonal proliferation of CD3+8+TCRαβ+ large granular lymphocytes (LGL) presenting multiple episodes of autoimmune cytopenia, including autoimmune neutropenia, idiopathic thrombocytopenic purpura, autoimmune haemolytic anaemia, and pure red cell aplasia. Each disorder appeared separately or as a combination during an 11-year clinical course. The increase of blood CD3+8+TCRαβ+ LGL was detected 6 years after the initial diagnosis of cytopenia, but the absolute number of LGL cells was always <1.0 x 109/1. LGL cells were of monoclonal origin and had a chromosomal abnormality. LGL cells transiently responded to cyclosporine A therapy, which was also effective on all of these autoimmune cytopenias. Accordingly, an undetectable level of proliferation of a clonal LGL population could cause various autoimmune haemopoietic disorders.

本文言語英語
ページ(範囲)670-673
ページ数4
ジャーナルBritish Journal of Haematology
107
3
DOI
出版ステータス出版済み - 1999

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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