Here we report a case of multiple dermatofibromas (MDF) arising in a patient with systemic lupus erythematosus (SLE) and Sjögren's syndrome. A 40-year-old woman with SLE and Sjögren's syndrome presented with a 5-year history of multiple cutaneous nodules. At the age of 33, she was diagnosed as having SLE and Sjögren's syndrome. Oral prednisolone was initiated and then tacrolimus was added at the age of 35. One month after the first administration of tacrolimus, she noticed a nodule on the chest. Similar nodules then appeared on the chest and limbs, eventually numbering 14 in total. Histologically, the nodule on the chest was composed of a proliferation of collagen bundles and spindle-shaped cells arranged in a storiform pattern in the dermis with reactive epidermal acanthosis, leading to the diagnosis of dermatofibroma. We have reviewed the comorbidity of MDF and internal diseases with special reference to SLE and Sjögren's syndrome.
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