Multiple gene duplication and expression of mouse bcl-2-related genes, A1

Shigetsugu Hatakeyama, Azumi Hamasaki, Izumi Negishi, Dennis Y. Loh, Fujiro Sendo, Keiko Nakayama, Kei Ichi Nakayama

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Here we report the genomic cloning and characterization of the murine A1 genes, which belong to the bcl-2 gene family. Southern analysis indicated the existence of at least four A1 genes in the murine genome and four different A1 genes, designated A1-a, -b, -c and -d, were cloned from the murine genomic library. The A1-a, -b and -d genes consisted of two exons, whereas the A1-c gene contained 1 bp insertion in the coding region which may result in an aberrant and truncated protein by frame-shift. With the exception of A1-c, the coding regions among A1 genes are highly conserved at > 97% at the nucleotide level and at > 96% at the amino acid level. A1-a, -b and -d genes appeared to be expressed specifically in organs containing many neutrophils. In neutrophils, A1-a, -b and -d transcripts were detected at a comparable level. Our data suggest that the multiple A1 genes in mice were generated by gene duplication and each of them may function as antiapoptotic molecules in neutrophils.

元の言語英語
ページ(範囲)631-637
ページ数7
ジャーナルInternational immunology
10
発行部数5
DOI
出版物ステータス出版済み - 5 26 1998

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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    Hatakeyama, S., Hamasaki, A., Negishi, I., Loh, D. Y., Sendo, F., Nakayama, K., & Nakayama, K. I. (1998). Multiple gene duplication and expression of mouse bcl-2-related genes, A1. International immunology, 10(5), 631-637. https://doi.org/10.1093/intimm/10.5.631