Multiple mechanisms for p27Kip1 translocation and degradation

Etsuo Susaki, Keiichi Nakayama

研究成果: ジャーナルへの寄稿評論記事

39 引用 (Scopus)

抄録

The nuclear export and rapid degradation of p27Kip1 at the G0-G1 transition are critical events for effective progression of the cell cycle. Several pathways have been proposed at the molecular level for the export of this cyclin-dependent kinase inhibitor from the nucleus. However, the addition of each new pathway renders the situation more complicated. We recently showed that cyclin D2 links growth signals to the cytoplasmic translocation and degradation of p27 at the G0-G 1 transition. Here we describe our findings and discuss how the multiple potential mechanisms for p27 translocation that precedes its degradation might be integrated in the context of growth stimulation and G 1 progression.

元の言語英語
ページ(範囲)3015-3020
ページ数6
ジャーナルCell Cycle
6
発行部数24
DOI
出版物ステータス出版済み - 12 15 2007

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Cyclin D2
Cell Nucleus Active Transport
Cyclin-Dependent Kinases
Growth
Cell Cycle

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

これを引用

Multiple mechanisms for p27Kip1 translocation and degradation. / Susaki, Etsuo; Nakayama, Keiichi.

:: Cell Cycle, 巻 6, 番号 24, 15.12.2007, p. 3015-3020.

研究成果: ジャーナルへの寄稿評論記事

Susaki, Etsuo ; Nakayama, Keiichi. / Multiple mechanisms for p27Kip1 translocation and degradation. :: Cell Cycle. 2007 ; 巻 6, 番号 24. pp. 3015-3020.
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