Multiple tumor suppressor 1 gene and esophageal carcinoma

J. Li, M. Mori, Y. Yang, H. Inoue, K. Mimori, K. Shibuta, H. Nakashima, K. I. Mafune, Y. Shimada, G. F. Barnard, K. Sugimachi, T. Akiyoshi

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The multiple tumor suppressor 1 (MTS1) gene is homozygously deleted frequently in cell lines derived from a wide variety of tumors. We investigated the deletion of the MTS1 gene in esophageal cancer cell lines and primary esophageal squamous carcinomas using the polymerase chain reaction. Sixteen and 15 of 23 esophageal cancer cell lines showed homozygous deletion of MTS1 exon 1 and exon 2, respectively, while none of 21 primary esophageal carcinomas showed the deletion. An analysis of MTS1 gene mutations was carried out by direct DNA sequencing in 8 cell lines and 21 primary carcinomas showing no homozygous deletion. In contrast to previous reports of esophageal carcinoma, there were no mutations recognized in the region sequenced. Our study suggests that the inactivation of the MTS1 gene may play an important role in esophageal carcinoma cell lines but may be less important in primary carcinomas of the human esophagus.

ジャーナルInternational journal of oncology
出版物ステータス出版済み - 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント Multiple tumor suppressor 1 gene and esophageal carcinoma' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Li, J., Mori, M., Yang, Y., Inoue, H., Mimori, K., Shibuta, K., Nakashima, H., Mafune, K. I., Shimada, Y., Barnard, G. F., Sugimachi, K., & Akiyoshi, T. (1995). Multiple tumor suppressor 1 gene and esophageal carcinoma. International journal of oncology, 7(2), 257-260.