Multiple umami receptors and their variants in human and mice

Masafumi Jyotaki, Noriatsu Shigemura, Yuzo Ninomiya

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

L-Glutamate and 5′-ribonucleotides are known to elicit a unique taste, "umami," that is distinct from the tastes of sweet, salt, sour and bitter. Recent progress in molecular biology has identified several umami receptor candidates, such as the heterodimer T1R1/T1R3, and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain- and taste-mGluR1 and mGluR4). This paper summarizes recent findings on the receptor system for umami taste. Most of the findings support the idea that multiple receptors exist for umami taste, at least in mice. The accumulating evidence indicates that the potential role of the signal mediated by the transduction pathway involving T1R1/T1R3 may be different from that mediated by the pathway involving mGluRs. The former signal occurs mainly in the anterior tongue, and plays a major role in preference behavior, whereas the latter occurs mainly in the posterior tongue, is active in mice lacking T1R3, Gα-gustducin, IP3R3 or TRPM5, and contributes to behavioral discrimination between umami and other taste compounds. In humans, unlike in mice, T1R1/T1R3 acts as an umami-specific receptor that can discriminate between umami and other tastes, and thus account for umami-linked preferences or discrimination.

元の言語英語
ページ(範囲)674-681
ページ数8
ジャーナルJournal of Health Science
55
発行部数5
DOI
出版物ステータス出版済み - 10 1 2009

Fingerprint

Brain
Ribonucleotides
Molecular biology
Glutamic Acid
Salts
Tongue
metabotropic glutamate receptor type 1
metabotropic glutamate receptor 4
Molecular Biology
Signal Transduction
gustducin

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

これを引用

Multiple umami receptors and their variants in human and mice. / Jyotaki, Masafumi; Shigemura, Noriatsu; Ninomiya, Yuzo.

:: Journal of Health Science, 巻 55, 番号 5, 01.10.2009, p. 674-681.

研究成果: ジャーナルへの寄稿評論記事

Jyotaki, Masafumi ; Shigemura, Noriatsu ; Ninomiya, Yuzo. / Multiple umami receptors and their variants in human and mice. :: Journal of Health Science. 2009 ; 巻 55, 番号 5. pp. 674-681.
@article{fb0a95f8b4144bf2853d475f1dbadbe5,
title = "Multiple umami receptors and their variants in human and mice",
abstract = "L-Glutamate and 5′-ribonucleotides are known to elicit a unique taste, {"}umami,{"} that is distinct from the tastes of sweet, salt, sour and bitter. Recent progress in molecular biology has identified several umami receptor candidates, such as the heterodimer T1R1/T1R3, and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain- and taste-mGluR1 and mGluR4). This paper summarizes recent findings on the receptor system for umami taste. Most of the findings support the idea that multiple receptors exist for umami taste, at least in mice. The accumulating evidence indicates that the potential role of the signal mediated by the transduction pathway involving T1R1/T1R3 may be different from that mediated by the pathway involving mGluRs. The former signal occurs mainly in the anterior tongue, and plays a major role in preference behavior, whereas the latter occurs mainly in the posterior tongue, is active in mice lacking T1R3, Gα-gustducin, IP3R3 or TRPM5, and contributes to behavioral discrimination between umami and other taste compounds. In humans, unlike in mice, T1R1/T1R3 acts as an umami-specific receptor that can discriminate between umami and other tastes, and thus account for umami-linked preferences or discrimination.",
author = "Masafumi Jyotaki and Noriatsu Shigemura and Yuzo Ninomiya",
year = "2009",
month = "10",
day = "1",
doi = "10.1248/jhs.55.674",
language = "English",
volume = "55",
pages = "674--681",
journal = "Journal of Health Science",
issn = "1344-9702",
publisher = "Pharmaceutical Society of Japan",
number = "5",

}

TY - JOUR

T1 - Multiple umami receptors and their variants in human and mice

AU - Jyotaki, Masafumi

AU - Shigemura, Noriatsu

AU - Ninomiya, Yuzo

PY - 2009/10/1

Y1 - 2009/10/1

N2 - L-Glutamate and 5′-ribonucleotides are known to elicit a unique taste, "umami," that is distinct from the tastes of sweet, salt, sour and bitter. Recent progress in molecular biology has identified several umami receptor candidates, such as the heterodimer T1R1/T1R3, and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain- and taste-mGluR1 and mGluR4). This paper summarizes recent findings on the receptor system for umami taste. Most of the findings support the idea that multiple receptors exist for umami taste, at least in mice. The accumulating evidence indicates that the potential role of the signal mediated by the transduction pathway involving T1R1/T1R3 may be different from that mediated by the pathway involving mGluRs. The former signal occurs mainly in the anterior tongue, and plays a major role in preference behavior, whereas the latter occurs mainly in the posterior tongue, is active in mice lacking T1R3, Gα-gustducin, IP3R3 or TRPM5, and contributes to behavioral discrimination between umami and other taste compounds. In humans, unlike in mice, T1R1/T1R3 acts as an umami-specific receptor that can discriminate between umami and other tastes, and thus account for umami-linked preferences or discrimination.

AB - L-Glutamate and 5′-ribonucleotides are known to elicit a unique taste, "umami," that is distinct from the tastes of sweet, salt, sour and bitter. Recent progress in molecular biology has identified several umami receptor candidates, such as the heterodimer T1R1/T1R3, and brain-expressed and taste-expressed type 1 and 4 metabotropic glutamate receptors (brain- and taste-mGluR1 and mGluR4). This paper summarizes recent findings on the receptor system for umami taste. Most of the findings support the idea that multiple receptors exist for umami taste, at least in mice. The accumulating evidence indicates that the potential role of the signal mediated by the transduction pathway involving T1R1/T1R3 may be different from that mediated by the pathway involving mGluRs. The former signal occurs mainly in the anterior tongue, and plays a major role in preference behavior, whereas the latter occurs mainly in the posterior tongue, is active in mice lacking T1R3, Gα-gustducin, IP3R3 or TRPM5, and contributes to behavioral discrimination between umami and other taste compounds. In humans, unlike in mice, T1R1/T1R3 acts as an umami-specific receptor that can discriminate between umami and other tastes, and thus account for umami-linked preferences or discrimination.

UR - http://www.scopus.com/inward/record.url?scp=70350230383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350230383&partnerID=8YFLogxK

U2 - 10.1248/jhs.55.674

DO - 10.1248/jhs.55.674

M3 - Review article

VL - 55

SP - 674

EP - 681

JO - Journal of Health Science

JF - Journal of Health Science

SN - 1344-9702

IS - 5

ER -