Muscarinic acetylcholine receptor subtypes in the human iris

Nobuto Ishizaka, Mami Noda, Shigeru Yokoyama, Kazuo Kawasaki, Miyuki Yamamoto, Haruhiro Higashida

研究成果: Contribution to journalArticle査読

29 被引用数 (Scopus)

抄録

Employing subtype-specific antisera, we measured the relative immunoreactivity of five muscarinic acetylcholine receptor (mAChR) subtype proteins (m1-m5) in the human iris. The most intensive FITC immunofluorescence was detected by the anti-m3 antibody, followed by anti-ml and -m5 antisera, in the iris sphincter muscle cells. Only very weak fluorescence was obtained by anti-m2 and -m4 antibodies. In dilator muscle cells, weak but not consistent immunoreactivity was found by anti-ml and -m5 antibodies. The results suggest that the m3 muscarinic receptor is the predominant subtype in sphincter muscle cells of the human iris.

本文言語英語
ページ(範囲)344-347
ページ数4
ジャーナルBrain Research
787
2
DOI
出版ステータス出版済み - 3 23 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

フィンガープリント 「Muscarinic acetylcholine receptor subtypes in the human iris」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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