Mutation analysis of the base-pair connecting two functional modules in the DSL ribozyme.

Junya Ishikawa, Hiroyuki Furuta, Yoshiya Ikawa

    研究成果: ジャーナルへの寄稿学術誌査読

    1 被引用数 (Scopus)

    抄録

    The class DSL ribozyme is one of artificial RNA enzymes generated by module-based molecular design. In the structure of this ribozyme, two most important functional modules are connected by a U-A base-pair. We have examined the possible importance of this base-pair by site-directed mutation experiments using the DSL-1S ribozyme and its derivative possessing altered modular organization. The analysis indicated that the DSL-1S ribozyme preferred U-A pair at the positions whereas the derivative preferred A-U pair.

    本文言語英語
    ページ(範囲)523-524
    ページ数2
    ジャーナルNucleic acids symposium series (2004)
    52
    出版ステータス出版済み - 12月 1 2008

    !!!All Science Journal Classification (ASJC) codes

    • 医学(全般)

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