Mutations affecting nerve attachment of Caenorhabditis elegans

G. Shioi, M. Shoji, M. Nakamura, T. Ishihara, I. Katsura, H. Fujisawa, S. Takagi

研究成果: Contribution to journalArticle査読

45 被引用数 (Scopus)

抄録

Using a pan-neuronal GFP marker, a morphological screen was performed to detect Caenorhabditis elegans larval lethal mutants with severely disorganized major nerve cords. We recovered and characterized 21 mutants that displayed displacement or detachment of the ventral nerve cord from the body wall (Ven: ventral cord abnormal). Six mutations defined three novel genetic loci: ven-1, ven-2, and ven-3. Fifteen mutations proved to be alleles of previously identified muscle attachment/positioning genes, mup-4, mua-1, mua-5, and mua-6. All the mutants also displayed muscle attachment/positioning defects characteristic of mua/mup mutants. The pan-neuronal GFP marker also revealed that mutants of other mua/mup loci, such as mup-1, mup-2 and mua-2, exhibited the Ven defect. The hypodermis, the excretory canal, and the gonad were morphologically abnormal in some of the mutants. The pleiotropic nature of the defects indicates that ven and mua/mup genes are required generally for the maintenance of attachment of tissues to the body wall in C. elegans.

本文言語英語
ページ(範囲)1611-1622
ページ数12
ジャーナルGenetics
157
4
出版ステータス出版済み - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Genetics

フィンガープリント 「Mutations affecting nerve attachment of Caenorhabditis elegans」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル