Mutations of the p53 gene in malignant rhabdoid tumors of soft tissue and the kidney: Immunohistochemical and DNA direct sequencing analysis

Yoshiaki Kinoshita, Hideki Shiratsuchi, Sadafumi Tamiya, Yumi Oshiro, Yoichi Hachitanda, Yoshinao Oda, Sachiyo Suita, Masazumi Tsuneyoshi

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

Malignant rhabdoid tumor (MRT) is characterized by the presence of intracytoplasmic eosinophilic inclusions composed of whorls of intermediate filaments. This tumor was originally described as an entity of the abortive type of Wilms' tumor in childhood. Recently, it has been proved that these rhabdoid cells can be observed in various types of malignant tumors, including soft tissue sarcoma or carcinoma. To investigate the oncogenesis of this tumor, we examined the p53 gene alteration by means of immunohistochemical analysis and DNA direct sequencing in three cases of malignant rhabdoid tumor (MRT) of the soft tissue and three cases of MRT of the kidney. All the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed immunopositivity for p53 protein. Among them, one of the cases of MRT of the soft tissue and two of the cases of MRT of the kidney showed missense mutations of the p53 gene. These results strongly suggest that p53 gene alterations may have an important role to play in the aggressive biological behavior and poor prognosis of this tumor.

本文言語英語
ページ(範囲)351-358
ページ数8
ジャーナルJournal of Cancer Research and Clinical Oncology
127
6
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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