Mutations of the silkworm molybdenum cofactor sulfurase gene, og, cause translucent larval skin

N. Kômoto, H. Sezutsu, K. Yukuhiro, Yutaka Banno, H. Fujii

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

Normal silkworms (Bombyx mori) have opaque larval skin due to uric acid accumulation in the epidermis while a mutant, og, is translucent owing to a deficiency in xanthine dehydrogenase (XDH), which synthesizes uric acid. Molybdenum cofactor (MoCo) sulfurase is responsible for XDH activation in various organisms. A silkworm MoCo sulfurase gene was cloned and found to be on the og locus, whose mutant alleles, ogk and ogt, show premature stop codons, proving that og is the MoCo sulfurase gene. It was observed that a miniature inverted-repeat transposable element (MITE), named Organdy, when inserted in an ogt mutant allele exon, causes unstable splicing of a downstream intron leading to incomplete open reading frames.

元の言語英語
ページ(範囲)417-427
ページ数11
ジャーナルInsect Biochemistry and Molecular Biology
33
発行部数4
DOI
出版物ステータス出版済み - 4 1 2003

Fingerprint

Bombyx
molybdenum
silkworms
Xanthine Dehydrogenase
xanthine dehydrogenase
Skin
Genes
uric acid
Uric Acid
mutation
mutants
Mutation
Alleles
miniature inverted repeat transposable elements
alleles
DNA Transposable Elements
genes
stop codon
Nonsense Codon
Bombyx mori

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Insect Science

これを引用

Mutations of the silkworm molybdenum cofactor sulfurase gene, og, cause translucent larval skin. / Kômoto, N.; Sezutsu, H.; Yukuhiro, K.; Banno, Yutaka; Fujii, H.

:: Insect Biochemistry and Molecular Biology, 巻 33, 番号 4, 01.04.2003, p. 417-427.

研究成果: ジャーナルへの寄稿記事

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AU - Fujii, H.

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