Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: Total synthesis and structure activity relationships

Mark B. Richardson, Shota Torigoe, Sho Yamasaki, Spencer J. Williams

    研究成果: Contribution to journalArticle査読

    29 被引用数 (Scopus)

    抄録

    Mycobacterium tuberculosis H37Ra produces a range of immunogenic β-gentiobiosyl diacylglycerides. We report the total synthesis of several candidate structures and show that these compounds signal weakly through mouse, but not human, Mincle. Structure-activity relationships reveal a striking dependence upon acyl chain length for gentiobiosyl diacylglyceride signalling through Mincle. Significantly, a truncated β-glucosyl diglyceride was shown to provide potent signalling through both human and mouse Mincle and could activate murine bone marrow derived dendritic cells.

    本文言語英語
    ページ(範囲)15027-15030
    ページ数4
    ジャーナルChemical Communications
    51
    81
    DOI
    出版ステータス出版済み - 8 20 2015

    All Science Journal Classification (ASJC) codes

    • 触媒
    • 電子材料、光学材料、および磁性材料
    • セラミックおよび複合材料
    • 化学 (全般)
    • 表面、皮膜および薄膜
    • 金属および合金
    • 材料化学

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