Myeloid Lineage Commitment from the Hematopoietic Stem Cell

Hiromi Iwasaki, Koichi Akashi

研究成果: ジャーナルへの寄稿総説査読

284 被引用数 (Scopus)

抄録

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal relationships among all blood-cell types and has allowed their developmental mechanisms to be assayed at the single-cell level. These isolated cell populations are used to elucidate the molecular mechanism of lineage fate decision and of its plasticity directly by stage-specific enforcement or repression of lineage-instructive signaling in purified cells. With an emphasis on the myeloid lineage, this review summarizes current concepts and controversies regarding adult murine hematopoietic development and discusses the potential mechanisms, operated by single or by multiple transcription factors, of myeloid lineage fate decision.

本文言語英語
ページ(範囲)726-740
ページ数15
ジャーナルImmunity
26
6
DOI
出版ステータス出版済み - 6月 22 2007

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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