Myocardial ischemia and metabolic disorder

研究成果: ジャーナルへの寄稿総説査読

1 被引用数 (Scopus)

抄録

During myocardial ischemia, the heart acutely adapts to the restricted supply of oxygen and substrates, and undergoes a dramatic switch from aerobic to anaerobic metabolism. However, this alteration in energy metabolism may cause calcium overload, the onset of mitochondrial permeability transition, and the activation of apoptotic cascades as well as reduced ATP synthesis in the myocardium, which contributes to a functional damage to the myocardium. Moreover, cardiac mitochondria are major sources of reactive oxygen species during ischemia, which may cause myocardial injury and contribute to poor recovery of myocardial dysfunction after reperfusion. Therefore, the modulation of mitochondrial function could be key therapeutics for cardiac protection during ischemia and reperfusion.

本文言語英語
ページ(範囲)621-624
ページ数4
ジャーナルNippon rinsho. Japanese journal of clinical medicine
68
4
出版ステータス出版済み - 4月 2010

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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