Myofibroblasts and inflammatory cells as players of cardiac fibrosis

Hitoshi Kurose, Supachoke Mangmool

研究成果: Contribution to journalReview article査読

27 被引用数 (Scopus)

抄録

On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis.

本文言語英語
ページ(範囲)1100-1113
ページ数14
ジャーナルArchives of Pharmacal Research
39
8
DOI
出版ステータス出版済み - 8 1 2016

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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