Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function

Chandrashekara Mallappa, Brian T. Nasipak, Letitiah Etheridge, Elliot J. Androphy, Stephen N. Jones, Charles G. Sagerström, Yasuyuki Ohkawa, Anthony N. Imbalzano

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)

抄録

Knockdown of the Brg1 ATPase subunit of SWI/SNF chromatin remodeling enzymes in developing zebrafish caused stunted tail formation and altered sarcomeric actin organization, which phenocopies the loss of the microRNA processing enzyme Dicer, or the knockdown of myogenic microRNAs. Furthermore, myogenic microRNA expression and differentiation was blocked in Brg1 conditional myoblasts differentiated ex vivo. The binding of Brg1 upstream of myogenic microRNA sequences correlated with MyoD binding and accessible chromatin structure in satellite cells and myofibers, and it was required for chromatin accessibility and microRNA expression in a tissue culture model for myogenesis. The results implicate ATP-dependent chromatin remodelers in myogenic microRNA gene regulation.

本文言語英語
ページ(範囲)3176-3186
ページ数11
ジャーナルMolecular and cellular biology
30
13
DOI
出版ステータス出版済み - 7月 2010

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 細胞生物学

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