N-acetyl-L-cysteine inhibits marble-burying behavior in mice

Nobuaki Egashira, Atsunori Shirakawa, Moe Abe, Tomiko Niki, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抜粋

In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant á-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.

元の言語英語
ページ(範囲)97-101
ページ数5
ジャーナルJournal of Pharmacological Sciences
119
発行部数1
DOI
出版物ステータス出版済み - 5 30 2012

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Egashira, N., Shirakawa, A., Abe, M., Niki, T., Mishima, K., Iwasaki, K., ... Fujiwara, M. (2012). N-acetyl-L-cysteine inhibits marble-burying behavior in mice. Journal of Pharmacological Sciences, 119(1), 97-101. https://doi.org/10.1254/jphs.11228SC