N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

Yukiko Nisikawa, Takao Shimazoe, Shigenobu Shibata, Shigenori Watanabe

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

元の言語英語
ページ(範囲)303-305
ページ数3
ジャーナルBrain Research
782
発行部数1-2
DOI
出版物ステータス出版済み - 1 26 1998
外部発表Yes

Fingerprint

Suprachiasmatic Nucleus
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
6-Cyano-7-nitroquinoxaline-2,3-dione
Synaptic Potentials
Optic Nerve
Acids
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. / Nisikawa, Yukiko; Shimazoe, Takao; Shibata, Shigenobu; Watanabe, Shigenori.

:: Brain Research, 巻 782, 番号 1-2, 26.01.1998, p. 303-305.

研究成果: ジャーナルへの寄稿記事

Nisikawa, Yukiko ; Shimazoe, Takao ; Shibata, Shigenobu ; Watanabe, Shigenori. / N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro. :: Brain Research. 1998 ; 巻 782, 番号 1-2. pp. 303-305.
@article{6e1f5c447c8a49ce9c638c77803c5e28,
title = "N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro",
abstract = "Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.",
author = "Yukiko Nisikawa and Takao Shimazoe and Shigenobu Shibata and Shigenori Watanabe",
year = "1998",
month = "1",
day = "26",
doi = "10.1016/S0006-8993(97)01177-3",
language = "English",
volume = "782",
pages = "303--305",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - N-methyl-D-aspartate receptors are indispensable for the formation of long-term potentiation in the rat suprachiasmatic nucleus in vitro

AU - Nisikawa, Yukiko

AU - Shimazoe, Takao

AU - Shibata, Shigenobu

AU - Watanabe, Shigenori

PY - 1998/1/26

Y1 - 1998/1/26

N2 - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

AB - Optic nerve (ON) stimulation caused a postsynaptic field potential in the suprachiasmatic nucleus (SCN) of rat hypothalamic slices. The postsynaptic field potential was suppressed by 6-cyano-7-nitroquinoxaline- 2,3-dione (CNQX), a non-NMDA receptor antagonist, in a concentration- dependent manner, but not affected by D-amino-5-phosphonovaleric acid (APV), a competitive NMDA receptor antagonist. Tetanic stimulation to the ON induced long-term potentiation (LTP) in the SCN. Application of APV at 50 μM inhibited the induction of LTP by tetanic stimulation but CNQX at lower dose (5 μM) didn't inhibit it. These results suggest that NMDA receptors are indispensable for the induction of LTP after tetanic stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0032567701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032567701&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(97)01177-3

DO - 10.1016/S0006-8993(97)01177-3

M3 - Article

C2 - 9519277

AN - SCOPUS:0032567701

VL - 782

SP - 303

EP - 305

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -