Nanobiodevice-based single biomolecule analysis, single-cell analysis, and in vivo imaging for cancer diagnosis, cancer theranostics, and iPS cell-based regenerative medicine

Noritada Kaji, Yoshinobu Baba

研究成果: Contribution to journalReview article査読

12 被引用数 (Scopus)

抄録

Numerous nanobiodevices have been developed for cancer diagnosis through the analysis of cancer cells and cancer-related biomolecules, cancer gene therapy, and iPS cell-based regenerative medicine. A microchamber array, which is fabricated on a plastic chip, enables to develop a reliable circulating tumor cell (CTC) detection technique for cancer metastasis diagnosis. A nanopillar-array or a nanowire-array on a quartz chip allows ultrafast analysis of DNA and microRNA within 1 s for the molecular diagnosis of cancer. Immunopillar devices, which contain a tremendous amount of antibody-immobilized microparticles inside an immunopillar structure, have realized fast and low invasive "from blood to analysis" type biomarker detection of cancer with a pM detection sensitivity within 5 min. Quantum dots and gene delivery nanodevices are applied to single cancer cell diagnosis, in vivo imaging for iPS cell based regenerative medicine, and theranostic devices for cancer diagnosis and therapy.

本文言語英語
ページ(範囲)859-864
ページ数6
ジャーナルanalytical sciences
30
9
DOI
出版ステータス出版済み - 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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