Nanobiodevices for biomolecule analysis and imaging

Takao Yasui, Noritada Kaji, Yoshinobu Baba

研究成果: ジャーナルへの寄稿総説査読

23 被引用数 (Scopus)

抄録

Nanobiodevices have been developed to analyze biomolecules and cells for biomedical applications. In this review, we discuss several nanobiodevices used for disease-diagnostic devices, molecular imaging devices, regenerative medicine, and drug-delivery systems and describe the numerous advantages of nanobiodevices, especially in biological, medical, and clinical applications. This review also outlines the fabrication technologies for nanostructures and nanomaterials, including top-down nanofabrication and bottom-up molecular self-assembly approaches. We describe nanopillar arrays and nanowall arrays for the ultrafast separation of DNA or protein molecules and nanoball materials for the fast separation of a wide range of DNA molecules, and we present examples of applications of functionalized carbon nanotubes to obtain information about subcellular localization on the basis of mobility differences between free fluorophores and fluorophore-labeled carbon nanotubes. Finally, we discuss applications of newly synthesized quantum dots to the screening of small interfering RNA, highly sensitive detection of disease-related proteins, and development of cancer therapeutics and diagnostics.

本文言語英語
ページ(範囲)83-96
ページ数14
ジャーナルAnnual Review of Analytical Chemistry
6
DOI
出版ステータス出版済み - 6月 2013
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分析化学

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