Nanocomposites of 2-arylpropionic acid drugs based on Mg-Al layered double hydroxide for dissolution enhancement

Mohamed R. Berber, Keiji Minagawa, Masahiro Katoh, Takeshi Mori, Masami Tanaka

    研究成果: ジャーナルへの寄稿学術誌査読

    47 被引用数 (Scopus)

    抄録

    Naproxen (NP) and flurpibrofen (FB) as non-steroidal anti-inflammatory drugs (NSAIDs) of 2-arylpropionic acid derivatives have been used as host organic drugs to be intercalated into layered double hydroxide (LDH) applying reconstruction and co-precipitation techniques. The obtained NP-LDH and FB-LDH nanocomposites were characterized by X-ray powder diffraction, infrared and thermogravimetric analyses. From drug loading, thermal analysis and X-ray measurements we can decide that coprecipitaion technique is better than reconstruction technique to obtain intercalated monophase nanocomposites. In acidic medium LDH dissolved and the intercalated drug starts to release in a molecular form which is suitable for adsorption. The drug solubility has been investigated before and after intercalation. It has been found that LDH improves the drug solubility and its dissolution rate.

    本文言語英語
    ページ(範囲)354-360
    ページ数7
    ジャーナルEuropean Journal of Pharmaceutical Sciences
    35
    4
    DOI
    出版ステータス出版済み - 11月 15 2008

    !!!All Science Journal Classification (ASJC) codes

    • 薬科学

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