Nanoparticle-mediated drug delivery system for coronary artery disease

Tetsuya Matoba, Jun Ichiro Koga, Kaku Nakano, Kensuke Egashira

研究成果: Contribution to journalReview article査読

抄録

Coronary artery disease including acute myocardial infarction is a significant concern in cardiovascular medicine, because of their high acute mortality and morbidity causing lethal heart failure. Atherosclerotic plaque destabilization and rupture are central pathogenesis of acute myocardial infarction, whereas myocardial ischemia-reperfusion injury is another adverse phenomenon in the heart undergoing early reperfusion therapy for acute myocardial infarction. There are un-met needs for these pathological conditions to be overcome by the use of nanoparticle-mediated drug delivery system (DDS). We provide overview of the mechanistic background for the use of DDS and the efficacy of nano-medicine in preclinical disease models.

本文言語英語
ページ(範囲)299-308
ページ数10
ジャーナルDrug Delivery System
30
4
DOI
出版ステータス出版済み - 12 25 2015

All Science Journal Classification (ASJC) codes

  • 薬科学

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