Nanoparticle-mediated endothelial cell-selective drug delivery system

Kaku Nakano, Jun Ichiro Koga, Kensuke Egashira

研究成果: 書籍/レポート タイプへの寄稿

1 被引用数 (Scopus)

抄録

Peripheral arterial disease (PAD) causes peripheral tissue ischemia, resulting in skin ulceration, gangrene, and limb amputation. The therapeutic goal is restoration of blood supply, and various treatments including exercise, medical therapy, and surgical revascularization are performed. The prognosis of critical limb ischemia, however, is still unsatisfactory, and there are unmet needs in developing novel therapeutics. We have been developing novel nanotechnology-based drug delivery system aiming efficient angiogenesis by delivering of HMG-CoA reductase inhibitor (statin) to endothelium. In this chapter, we summarized current developing status of nanotechnology-based drug delivery system including animal experiments and ongoing clinical trials (CLINICAL TRIAL REGISTRATION NUMBER: UMIN000008011).

本文言語英語
ホスト出版物のタイトルTherapeutic Angiogenesis
出版社Springer Singapore
ページ247-266
ページ数20
ISBN(電子版)9789811027444
ISBN(印刷版)9789811027437
DOI
出版ステータス出版済み - 7月 11 2017

!!!All Science Journal Classification (ASJC) codes

  • 工学(全般)
  • コンピュータ サイエンス(全般)

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