Nanopillar, nanoball, and nanofibers for highly efficient analysis of biomolecules

Noritada Kaji, Yukihiro Okamoto, Manabu Tokeshi, Yoshinobu Baba

研究成果: Contribution to journalArticle査読

56 被引用数 (Scopus)

抄録

DNA separation technologies combined with micro- and nanofabrication technologies found a breakthrough in genotyping and DNA sequencing. This tutorial review outlines the fabrication technologies for nano-scaled structures inside microchannels and how the precisely designed structures contribute to obtaining higher performances in DNA separations from the viewpoint of the fabrication process, “top-down” nanofabrication and “bottom-up” molecular self-assembly approaches. It was found that these nanofabricated structures generated the unique separation modes that could not be achieved by random-sized pores of conventional gel or polymer systems. Furthermore, it was found that nanoscale-specific phenomena such as electroosmotic flow should be taken into consideration for further development of nanofabricated structures in DNA analysis. These separation technologies will contribute as a core technology for a future integrated biomolecule anlaysis chip.

本文言語英語
ページ(範囲)948-956
ページ数9
ジャーナルChemical Society Reviews
39
3
DOI
出版ステータス出版済み - 2 24 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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