Nanoscale swimmers: Hydrodynamic interactions and propulsion of molecular machines

T. Sakaue, R. Kapral, A. S. Mikhailov

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

抜粋

Molecular machines execute nearly regular cyclic conformational changes as a result of ligand binding and product release. This cyclic conformational dynamics is generally non-reciprocal so that under time reversal a different sequence of machine conformations is visited. Since such changes occur in a solvent, coupling to solvent hydrodynamic modes will generally result in self-propulsion of the molecular machine. These effects are investigated for a class of coarse grained models of protein machines consisting of a set of beads interacting through pair-wise additive potentials. Hydrodynamic effects are incorporated through a configuration-dependent mobility tensor, and expressions for the propulsion linear and angular velocities, as well as the stall force, are obtained. In the limit where conformational changes are small so that linear response theory is applicable, it is shown that propulsion is exponentially small; thus, propulsion is nonlinear phenomenon. The results are illustrated by computations on a simple model molecular machine.

元の言語英語
ページ(範囲)381-387
ページ数7
ジャーナルEuropean Physical Journal B
75
発行部数3
DOI
出版物ステータス出版済み - 6 1 2010

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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