Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice

Shigeo Yura, Hiroaki Itoh, Norimasa Sagawa, Hiroshi Yamamoto, Hiroaki Masuzaki, Kazuwa Nakao, Makoto Kawamura, Haruta Mogami, Yoshihiro Ogawa, Shingo Fujii

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

抄録

Objective: Epidemiological evidence has revealed that undernutrition in utero is closely associated with obesity and related detrimental metabolic sequelae in adulthood. Recently, using a wild-type (wt) mouse model in which offspring were exposed to intrauterine undernutrition (UN offspring), we reported that the premature leptin surge during neonatal growth promotes lifelong changes in energy regulating circuitry in the hypothalamus, thus playing an important role in the development of pronounced obesity on a high-fat diet (HFD) in adulthood. Here, we further evaluate the essential involvement of leptin in the developmental origins of obesity using leptin-deficient ob/ob mice. Methods and Procedures: We assessed the progression of obesity on an HFD in adult leptin-deficient ob/ob male mice that were exposed to intrauterine undernutrition by maternal food restriction (ob/ob UN offspring) or to leptin treatment during the neonatal period; this treatment is comparable to the premature leptin surge observed in the wt-UN offspring. Results: On an HFD, the body weight of the male ob/ob UN offspring paralleled that of the ob/ob offspring exposed to normal intrauterine nutrition (ob/ob NN offspring). In contrast, early exposure to leptin in the ob/ob NN offspring during early neonatal growth reproduced the development of pronounced obesity on an HFD in adulthood. Discussion: The presence of leptin and associated energy regulation are indispensable in the acceleration of obesity on an HFD caused by undernutrition in utero. The premature leptin surge plays an essential role in the developmental origins of obesity as a programming signal during the early neonatal period.

元の言語英語
ページ(範囲)1289-1295
ページ数7
ジャーナルObesity
16
発行部数6
DOI
出版物ステータス出版済み - 6 1 2008
外部発表Yes

Fingerprint

Leptin
Obesity
Diet
High Fat Diet
United Nations
Malnutrition
Growth and Development
Hypothalamus
Body Weight
Mothers
Food
Growth

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

これを引用

Yura, S., Itoh, H., Sagawa, N., Yamamoto, H., Masuzaki, H., Nakao, K., ... Fujii, S. (2008). Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice. Obesity, 16(6), 1289-1295. https://doi.org/10.1038/oby.2008.57

Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice. / Yura, Shigeo; Itoh, Hiroaki; Sagawa, Norimasa; Yamamoto, Hiroshi; Masuzaki, Hiroaki; Nakao, Kazuwa; Kawamura, Makoto; Mogami, Haruta; Ogawa, Yoshihiro; Fujii, Shingo.

:: Obesity, 巻 16, 番号 6, 01.06.2008, p. 1289-1295.

研究成果: ジャーナルへの寄稿記事

Yura, S, Itoh, H, Sagawa, N, Yamamoto, H, Masuzaki, H, Nakao, K, Kawamura, M, Mogami, H, Ogawa, Y & Fujii, S 2008, 'Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice', Obesity, 巻. 16, 番号 6, pp. 1289-1295. https://doi.org/10.1038/oby.2008.57
Yura S, Itoh H, Sagawa N, Yamamoto H, Masuzaki H, Nakao K その他. Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice. Obesity. 2008 6 1;16(6):1289-1295. https://doi.org/10.1038/oby.2008.57
Yura, Shigeo ; Itoh, Hiroaki ; Sagawa, Norimasa ; Yamamoto, Hiroshi ; Masuzaki, Hiroaki ; Nakao, Kazuwa ; Kawamura, Makoto ; Mogami, Haruta ; Ogawa, Yoshihiro ; Fujii, Shingo. / Neonatal exposure to leptin augments diet-induced obesity in leptin-deficient ob/ob mice. :: Obesity. 2008 ; 巻 16, 番号 6. pp. 1289-1295.
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