Neural regulation of blood pressure by leptin and the related peptides

Kiyoshi Matsumura, Takuya Tsuchihashi, Koji Fujii, Mitsuo Iida

    研究成果: Contribution to journalReview article査読

    78 被引用数 (Scopus)

    抄録

    Recent biological advances make it possible to discover new peptides associated with obesity. Leptin, neuropeptide Y, corticotrophin-releasing factor (CRF), α-melanocyte stimulating hormone (α-MSH), and cocaine- and amphetamine-regulated transcript (CART) peptides are known to participate in appetite and feeding behavior. Various lines of evidence suggest that these peptides participate not only in feeding behavior but also in cardiovascular and sympathetic regulations. Both leptin and ghrelin are secreted from the peripheral tissue; then they reach the brain to modulate sympathetic activity. These two peptides seem to play important roles to transmit peripheral metabolic information to the brain, and to convert it to cardiovascular and sympathetic information. Leptin activates neurons containing α-melanocyte stimulating hormone and cocaine- and amphetamine-regulated transcript peptides, resulting in increases in sympathetic activity and blood pressure. Cardiovascular action of α-melanocyte stimulating hormone is mediated through melanocortin-4 receptor, and agouti-related protein (AGRP) plays a role as an endogenous melanocortin-4 receptor antagonist. In contrast, ghrelin and neuropeptide Y in the brain suppress sympathetic activity and decrease blood pressure. Depressor and sympathoinhibitory effects of central neuropeptide Y are inhibited by leptin. Furthermore, central ghrelin modulates baroreflex control of renal sympathetic nerve activity and heart rate. Thus, leptin and the related peptides, which participate in appetite and feeding behavior, seem to function together to regulate cardiovascular system and sympathetic nerve activity, and may play a key role in the association between obesity and hypertension.

    本文言語英語
    ページ(範囲)79-86
    ページ数8
    ジャーナルRegulatory Peptides
    114
    2-3
    DOI
    出版ステータス出版済み - 7 15 2003

    All Science Journal Classification (ASJC) codes

    • 生化学
    • 生理学
    • 内分泌学
    • 臨床生化学
    • 細胞および分子神経科学

    フィンガープリント

    「Neural regulation of blood pressure by leptin and the related peptides」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル