抄録
Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75–84, 2018.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 75-84 |
| ページ数 | 10 |
| ジャーナル | Developmental Dynamics |
| 巻 | 247 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | 出版済み - 1 2018 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
これを引用
Neural stem cell therapy aiming at better functional recovery after spinal cord injury. / Zhu, Yicheng; Uezono, Naohiro; Yasui, Tetsuro; Nakashima, Kinichi.
：: Developmental Dynamics, 巻 247, 番号 1, 01.2018, p. 75-84.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Neural stem cell therapy aiming at better functional recovery after spinal cord injury
AU - Zhu, Yicheng
AU - Uezono, Naohiro
AU - Yasui, Tetsuro
AU - Nakashima, Kinichi
PY - 2018/1
Y1 - 2018/1
N2 - Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75–84, 2018.
AB - Injury to the spinal cord causes transection of axon fibers and neural cell death, resulting in disruption of the neural network and severe functional loss. Reconstruction of the damaged neural circuits was once considered to be hopeless as the adult mammalian central nervous system has very poor ability to regenerate. For this reason, there is currently no effective therapeutic treatment for spinal cord injury (SCI). However, with recent developments in stem cell research and cell culture technology, regenerative therapy using neural stem cell (NSC) transplantation has rapidly been developed, and this therapeutic strategy makes it possible to rebuild the destroyed neural circuits. In this review, we discuss the recent breakthroughs in NSC transplantation therapy for SCI. Developmental Dynamics 247:75–84, 2018.
UR - http://www.scopus.com/inward/record.url?scp=85028939749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028939749&partnerID=8YFLogxK
U2 - 10.1002/dvdy.24558
DO - 10.1002/dvdy.24558
M3 - Review article
C2 - 28766845
AN - SCOPUS:85028939749
VL - 247
SP - 75
EP - 84
JO - Developmental Dynamics
JF - Developmental Dynamics
SN - 1058-8388
IS - 1
ER -