Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study

Noriaki Hirakawa, Hironori Kuga, Yoji Hirano, Jinya Sato, Naoya Oribe, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Yuko Oda, Osamu Togao, Akio Hiwatashi, Hiroshi Honda, Shigenobu Kanba, Toshiaki Onitsuka

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the neural substrate of EPS. T1-weighted images were analyzed in 14 patients with EPS and 14 strictly-matched patients with EP. We conducted volume comparison in the whole brain using voxel-based morphometry (VBM). The VBM method revealed that EPS patients exhibited significantly reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus compared with EP patients (adjusted p = 0.029, FDR corrected q; k = 319 voxels). For clinical correlations, there were no significant associations between psychotic symptoms and gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus. VBM analysis revealed that reduced gray matter volumes in the left postcentral gyrus and the left supra marginal gyrus may be crucial regions for EPS.

本文言語英語
ページ(範囲)1382-1387
ページ数6
ジャーナルBrain Imaging and Behavior
14
5
DOI
出版ステータス出版済み - 10月 1 2020

!!!All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング
  • 神経学
  • 臨床神経学
  • 認知神経科学
  • 細胞および分子神経科学
  • 精神医学および精神衛生
  • 行動神経科学

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