Neurodegeneration augments the ability of bone marrow-derived mesenchymal stem cells to fuse with Purkinje neurons in Niemann-Pick type C mice

Jae Sung Bae, Shigeki Furuya, Yoko Shinoda, Shogo Endo, Edward H. Schuchman, Yoshio Hirabayashi, Hee Kyung Jin

研究成果: Contribution to journalArticle査読

66 被引用数 (Scopus)

抄録

After transplantation, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) may undergo transdifferentiation and/or cell fusion in response to new environments. However, the mechanism(s) that govern these cell fate switches remain unknown. Here we demonstrate that the pathology associated with murine Niemann-Pick disease type C (NP-C) cerebellum augments the ability of BM-MSCs to fuse with Purkinje neurons. The results suggest that the degenerative microenvironment of Purkinje neurons in the NP-C cerebellum modulates the cell fate switch of BM-MSCs via cell fusion.

本文言語英語
ページ(範囲)1006-1011
ページ数6
ジャーナルHuman Gene Therapy
16
8
DOI
出版ステータス出版済み - 8 1 2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 分子生物学
  • 遺伝学

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