Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age

Hirosuke Inoue, Masayuki Ochiai, Yasunari Sakai, Kazuaki Yasuoka, Koichi Tanaka, Masako Ichiyama, Hiroaki Kurata, Junko Fujiyoshi, Yuki Matsushita, Satoshi Honjo, Kazuaki Nonaka, Tomoaki Taguchi, Kiyoko Kato, Shouichi Ohga

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

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OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7% of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1% (95% confidence interval [CI]: 54.6%-63.5%). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95% CI: 1.19-1.68; P <.01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95% CI: 1.13-1.73; P <.01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95% CI: 1.07-1.60; P <.01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95% CI: 1.09-1.54; P <.01), and male sex (adjusted RR: 1.19; 95% CI: 1.01-2.40; P =.04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.

元の言語英語
記事番号e20174286
ジャーナルPediatrics
142
発行部数6
DOI
出版物ステータス出版済み - 12 2018

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Birth Weight
Confidence Intervals
Odds Ratio
Periventricular Leukomalacia
Necrotizing Enterocolitis
Patent Ductus Arteriosus
Intracranial Hemorrhages
Vision Disorders
Cerebral Palsy
Hearing Loss
Nervous System
Ligation
Japan
Multivariate Analysis
Regression Analysis
Hemorrhage
Morbidity
Research
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age. / Inoue, Hirosuke; Ochiai, Masayuki; Sakai, Yasunari; Yasuoka, Kazuaki; Tanaka, Koichi; Ichiyama, Masako; Kurata, Hiroaki; Fujiyoshi, Junko; Matsushita, Yuki; Honjo, Satoshi; Nonaka, Kazuaki; Taguchi, Tomoaki; Kato, Kiyoko; Ohga, Shouichi.

:: Pediatrics, 巻 142, 番号 6, e20174286, 12.2018.

研究成果: ジャーナルへの寄稿記事

Inoue, Hirosuke ; Ochiai, Masayuki ; Sakai, Yasunari ; Yasuoka, Kazuaki ; Tanaka, Koichi ; Ichiyama, Masako ; Kurata, Hiroaki ; Fujiyoshi, Junko ; Matsushita, Yuki ; Honjo, Satoshi ; Nonaka, Kazuaki ; Taguchi, Tomoaki ; Kato, Kiyoko ; Ohga, Shouichi. / Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age. :: Pediatrics. 2018 ; 巻 142, 番号 6.
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title = "Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age",
abstract = "OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7{\%} of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1{\%} (95{\%} confidence interval [CI]: 54.6{\%}-63.5{\%}). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95{\%} CI: 1.19-1.68; P <.01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95{\%} CI: 1.13-1.73; P <.01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95{\%} CI: 1.07-1.60; P <.01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95{\%} CI: 1.09-1.54; P <.01), and male sex (adjusted RR: 1.19; 95{\%} CI: 1.01-2.40; P =.04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.",
author = "Hirosuke Inoue and Masayuki Ochiai and Yasunari Sakai and Kazuaki Yasuoka and Koichi Tanaka and Masako Ichiyama and Hiroaki Kurata and Junko Fujiyoshi and Yuki Matsushita and Satoshi Honjo and Kazuaki Nonaka and Tomoaki Taguchi and Kiyoko Kato and Shouichi Ohga",
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T1 - Neurodevelopmental outcomes in infants with birth weight ≤500 g at 3 years of age

AU - Inoue, Hirosuke

AU - Ochiai, Masayuki

AU - Sakai, Yasunari

AU - Yasuoka, Kazuaki

AU - Tanaka, Koichi

AU - Ichiyama, Masako

AU - Kurata, Hiroaki

AU - Fujiyoshi, Junko

AU - Matsushita, Yuki

AU - Honjo, Satoshi

AU - Nonaka, Kazuaki

AU - Taguchi, Tomoaki

AU - Kato, Kiyoko

AU - Ohga, Shouichi

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7% of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1% (95% confidence interval [CI]: 54.6%-63.5%). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95% CI: 1.19-1.68; P <.01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95% CI: 1.13-1.73; P <.01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95% CI: 1.07-1.60; P <.01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95% CI: 1.09-1.54; P <.01), and male sex (adjusted RR: 1.19; 95% CI: 1.01-2.40; P =.04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.

AB - OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7% of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1% (95% confidence interval [CI]: 54.6%-63.5%). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95% CI: 1.19-1.68; P <.01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95% CI: 1.13-1.73; P <.01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95% CI: 1.07-1.60; P <.01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95% CI: 1.09-1.54; P <.01), and male sex (adjusted RR: 1.19; 95% CI: 1.01-2.40; P =.04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.

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