Neuroendocrine tumor of the pancreas with rhabdoid feature

Tetsuyuki Miyazaki, Shinichi Aishima, Minoru Fujino, Keigo Ozono, yuichiro kubo, yasuhiro ushijima, Takashi Osoegawa, Eikichi Ihara, Itou Tetsuhide, Ohtsuka Takao, Masafumi Nakamura, Yoshinao Oda

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Imaging of a 53-year-old Japanese man revealed two tumors in the liver and a tumor in the head of the pancreas with a swelling lymph node. A needle biopsy for the liver tumors was performed, revealing a neuroendocrine tumor. Enucleation, lymphadenectomy, and partial hepatectomy were performed. The microscopic examination identified many tumor cells with intracytoplasmic inclusions arranged in a nested, cord, or tubular fashion. The intracytoplasmic inclusions displayed densely eosinophilic globules and displaced the nuclei toward the periphery, which constitutes “rhabdoid” features. The tumor cells were positive for synaptophysin and weakly positive for NCAM, but negative for chromogranin A. Epithelial markers (AE1/AE3 and CAM5.2) accentuated intracytoplasmic globules. Pancreatic neuroendocrine tumors with rhabdoid features are very rare. Generally, rhabdoid features are aggressive and dedifferentiated characteristics of various types of tumor. Pancreatic neuroendocrine tumors containing rhabdoid cells tend to display extrapancreatic spread at the time of presentation, although some of these tumors with rhabdoid features are not always associated with aggressive behavior.

元の言語英語
ページ(範囲)247-252
ページ数6
ジャーナルVirchows Archiv
473
発行部数2
DOI
出版物ステータス出版済み - 8 1 2018

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Neuroendocrine Tumors
Pancreas
Neoplasms
Rhabdoid Tumor
Neural Cell Adhesion Molecules
Chromogranin A
Synaptophysin
Liver
Hepatectomy
Needle Biopsy
Lymph Node Excision
Lymph Nodes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

これを引用

Neuroendocrine tumor of the pancreas with rhabdoid feature. / Miyazaki, Tetsuyuki; Aishima, Shinichi; Fujino, Minoru; Ozono, Keigo; kubo, yuichiro; ushijima, yasuhiro; Osoegawa, Takashi; Ihara, Eikichi; Tetsuhide, Itou; Takao, Ohtsuka; Nakamura, Masafumi; Oda, Yoshinao.

:: Virchows Archiv, 巻 473, 番号 2, 01.08.2018, p. 247-252.

研究成果: ジャーナルへの寄稿記事

Miyazaki, Tetsuyuki ; Aishima, Shinichi ; Fujino, Minoru ; Ozono, Keigo ; kubo, yuichiro ; ushijima, yasuhiro ; Osoegawa, Takashi ; Ihara, Eikichi ; Tetsuhide, Itou ; Takao, Ohtsuka ; Nakamura, Masafumi ; Oda, Yoshinao. / Neuroendocrine tumor of the pancreas with rhabdoid feature. :: Virchows Archiv. 2018 ; 巻 473, 番号 2. pp. 247-252.
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AU - ushijima, yasuhiro

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