Neuron-specific γ-enolase derived from human glioma

Masaharu Kuramitsu, Hiroki Sawa, Iwao Takeshita, Toru Iwaki, Kanefusa Kato

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Neuron-specific γ-enolase in human neurogenic tumors, including gliomas, transplanted gliomas, and permanent human glioma cell lines, was studied quantitatively, using newly established enzyme immunoassay methods, together with immunostaining of the tissue and cell preparations. A significantly high level of γ-enolase was found in some glioblastomas, astrocytomas and oligodendrogliomas as well as medulloblastomas. Glioblastomas transplanted into mice and cultured cell lines derived from the same origins, as well as the permanent human glioma cell lines, also contained γ-enolase, although the contents were low compared with findings in the original tumor tissues. Immunohistochemically, γ-enolase stained intensely in the glioblastomatous cells. Serum γ-enolase concentrations in some patients with gliomas and those of all the transplanted mice were enhanced. The serum γ-enolase levels in the mice correlated well with size of the transplanted tumor tissues. These results indicate that neuron-specific γ-enolase is produced in some neurogenic tumors of nonneuronal origin, therefore, serum γ-enolase may be a useful biomarker for monitoring the extent of disease in patients with gliomas.

本文言語英語
ページ(範囲)89-105
ページ数17
ジャーナルNeurochemical Pathology
4
2
DOI
出版ステータス出版済み - 4 1 1986

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学

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