Neuronal stem/progenitor cells in the vertebrate eye

Kunimasa Ohta, Ayako Ito, Hideaki Tanaka

研究成果: ジャーナルへの寄稿総説査読

38 被引用数 (Scopus)

抄録

We acquire information from the outside world through our eyes which contain the retina, the photosensitive component of the central nervous system. Once the adult mammalian retina is damaged, the retinal neuronal death causes a severe loss of visual function. It has been believed that the adult mammalian retina had no regenerative capacity. However, the identification of neuronal progenitor cells in the retina sheds some light on cellular therapies for damaged retinal regeneration. In this review, we highlight three potential stem/progenitor cells in the eye, the ciliary body epithelium cells, the iris pigmented epithelium cells, and Müller glia. In order to make them prime candidates for the possible treatment of retinal diseases, it is important to understand their basic characters. In addition, we discuss the key signaling molecules that function extracellularly and determine whether neuronal progenitors remain quiescent, proliferate, or differentiate. Finally, we introduce a secreted protein, Tsukushi, which is a possible candidate as a niche molecule for retinal stem/progenitor cells.

本文言語英語
ページ(範囲)253-259
ページ数7
ジャーナルDevelopment Growth and Differentiation
50
4
DOI
出版ステータス出版済み - 5月 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学

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