Neuroprotective effect of theanine on cerebral ischemia

Nobuaki Egashira, Kenichi Mishima, Katsunori Iwasaki, Ryozo Oishi, Michihiro Fujiwara

研究成果: 著書/レポートタイプへの貢献

抄録

The present article introduces our study related to the neuroprotective effect of γ-glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on cerebral ischemia. Theanine (1 mg/kg) significantly decreased the size of the cerebral infarcts in a 4 h middle cerebral artery (MCA) occlusion model in mice. However, theanine did not affect the cerebral blood flow, brain temperature and physiological variables (pH, pCO2, pO2 and hematocrit) in this model. Theanine also reduced the alterations of NeuN (neuron), GFAP (astrocyte) and Iba 1 (microglia) expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline, γ-aminobutyric acidA (GABAA) receptor antagonist, but not 3-mercaptopropionic acid, glutamate decarboxylase inhibitor. Furthermore, theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to twice-repeated cerebral ischemia, 7 days after the second reperfusion. In addition, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine directly provides neuroprotection against cerebral ischemia and its neuroprotective effect is mediated, at least in part, by GABAA receptors, and that it may be clinically useful for preventing cerebrovascular disease.

元の言語英語
ホスト出版物のタイトルHandbook of Green Tea and Health Research
出版者Nova Science Publishers, Inc.
ページ207-218
ページ数12
ISBN(印刷物)9781607410454
出版物ステータス出版済み - 2 2009

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Neuroprotective Agents
Brain Ischemia
Middle Cerebral Artery Infarction
Cerebrovascular Circulation
3-Mercaptopropionic Acid
Camellia sinensis
GABA-A Receptor Antagonists
Cerebrovascular Disorders
Glutamate Decarboxylase
Bicuculline
theanine
Microglia
Tea
GABA-A Receptors
Hematocrit
Astrocytes
Reperfusion
Cell Count
Neurons
Temperature

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Egashira, N., Mishima, K., Iwasaki, K., Oishi, R., & Fujiwara, M. (2009). Neuroprotective effect of theanine on cerebral ischemia. : Handbook of Green Tea and Health Research (pp. 207-218). Nova Science Publishers, Inc..

Neuroprotective effect of theanine on cerebral ischemia. / Egashira, Nobuaki; Mishima, Kenichi; Iwasaki, Katsunori; Oishi, Ryozo; Fujiwara, Michihiro.

Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., 2009. p. 207-218.

研究成果: 著書/レポートタイプへの貢献

Egashira, N, Mishima, K, Iwasaki, K, Oishi, R & Fujiwara, M 2009, Neuroprotective effect of theanine on cerebral ischemia. : Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., pp. 207-218.
Egashira N, Mishima K, Iwasaki K, Oishi R, Fujiwara M. Neuroprotective effect of theanine on cerebral ischemia. : Handbook of Green Tea and Health Research. Nova Science Publishers, Inc. 2009. p. 207-218
Egashira, Nobuaki ; Mishima, Kenichi ; Iwasaki, Katsunori ; Oishi, Ryozo ; Fujiwara, Michihiro. / Neuroprotective effect of theanine on cerebral ischemia. Handbook of Green Tea and Health Research. Nova Science Publishers, Inc., 2009. pp. 207-218
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