Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia

Kotaro Takasaki, Kanako Uchida, Risako Fujikawa, Ai Nogami, Kazuya Nakamura, Chihiro Kawasaki, Kazuko Yamaguchi, Masahiko Morita, Koji Morishita, Kaori Kubota, Shutaro Katsurabayashi, Kenichi Mishima, Michihiro Fujiwara, Katsunori Iwasaki

研究成果: Contribution to journalArticle

18 引用 (Scopus)

抜粋

Citidine-5-diphosphocholine or citicoline (CDP-choline) is used as a neuroprotective and memory-enhancing drug in cerebral stroke, Alzheimer's disease, and other neurovascular diseases. Non-clinical studies have demonstrated the neuroprotective effects of CDP-choline in ischemic animal models. However, the relationship between the neuroprotective effect and the memory enhancing effect of CDP-choline is still unknown. No studies have demonstrated the ameliorative effect on impaired spatial memory and the suppressive effect on neuronal cell death of CDP-choline in the same model. In this study, we examined the effect of CDP-choline on impaired spatial memory and hippocampal CA1 neuronal death in rats subjected to repeated cerebral ischemia, and we compared the mechanism of CDP-choline to that of donepezil. Seven days post administration of CDP-choline (100, 300, 1000 mg/kg per day, p.o.) or donepezil increased correct choices and reduced error choices in an eight-arm radial maze task in a dose-dependent manner. Neuronal cell death of caspase-3 protein-positive neurons in the hippocampus were reduced by repeated administration of CDP-choline at the highest dose. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory via hippocampal neuronal cell death in a rat model of cerebral ischemia.

元の言語英語
ページ(範囲)232-237
ページ数6
ジャーナルJournal of Pharmacological Sciences
116
発行部数2
DOI
出版物ステータス出版済み - 6 24 2011
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

フィンガープリント Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takasaki, K., Uchida, K., Fujikawa, R., Nogami, A., Nakamura, K., Kawasaki, C., Yamaguchi, K., Morita, M., Morishita, K., Kubota, K., Katsurabayashi, S., Mishima, K., Fujiwara, M., & Iwasaki, K. (2011). Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia. Journal of Pharmacological Sciences, 116(2), 232-237. https://doi.org/10.1254/jphs.11013FP