Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats

Fengling Pu, Kyoko Motohashi, Tomohiro Kaneko, Yurika Tanaka, Naomi Manome, Keiichi Irie, Jirou Takata, Nobuaki Egashira, Ryozo Oishi, Takuya Okamoto, Yasuo Sei, Takako Yokozawa, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.

元の言語英語
ページ(範囲)424-430
ページ数7
ジャーナルJournal of Pharmacological Sciences
109
発行部数3
DOI
出版物ステータス出版済み - 6 22 2009

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Neuroprotective Agents
Brain Ischemia
Cerebrovascular Circulation
Hippocampal CA1 Region
Laser-Doppler Flowmetry
Kangen-karyu
Spatial Memory
Aspirin
Reperfusion
Brain

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

これを引用

Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats. / Pu, Fengling; Motohashi, Kyoko; Kaneko, Tomohiro; Tanaka, Yurika; Manome, Naomi; Irie, Keiichi; Takata, Jirou; Egashira, Nobuaki; Oishi, Ryozo; Okamoto, Takuya; Sei, Yasuo; Yokozawa, Takako; Mishima, Kenichi; Iwasaki, Katsunori; Fujiwara, Michihiro.

:: Journal of Pharmacological Sciences, 巻 109, 番号 3, 22.06.2009, p. 424-430.

研究成果: ジャーナルへの寄稿記事

Pu, F, Motohashi, K, Kaneko, T, Tanaka, Y, Manome, N, Irie, K, Takata, J, Egashira, N, Oishi, R, Okamoto, T, Sei, Y, Yokozawa, T, Mishima, K, Iwasaki, K & Fujiwara, M 2009, 'Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats', Journal of Pharmacological Sciences, 巻. 109, 番号 3, pp. 424-430. https://doi.org/10.1254/jphs.08245FP
Pu, Fengling ; Motohashi, Kyoko ; Kaneko, Tomohiro ; Tanaka, Yurika ; Manome, Naomi ; Irie, Keiichi ; Takata, Jirou ; Egashira, Nobuaki ; Oishi, Ryozo ; Okamoto, Takuya ; Sei, Yasuo ; Yokozawa, Takako ; Mishima, Kenichi ; Iwasaki, Katsunori ; Fujiwara, Michihiro. / Neuroprotective effects of kangen-karyu on spatial memory impairment in an 8-arm radial maze and neuronal death in the hippocampal ca1 region induced by repeated cerebral ischemia in rats. :: Journal of Pharmacological Sciences. 2009 ; 巻 109, 番号 3. pp. 424-430.
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abstract = "In the present study, we investigated the neuroprotective effects of Kangen-karyu (KGK) in a repeated cerebral ischemia model (2 x 10 min, 1-h interval). A 21-day pre- and post- ischemic treatment with KGK (10-300mg/kg) and aspirin (5mg/kg) improved the spatial memory impairment and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia. However, a 7-day post-ischemic treatment with KGK did not attenuate the spatial memory impairment and neuronal death in this model. To determine the mechanism of action of KGK, we investigated the effects of a 14-day pre-ischemic treatment with KGK on cerebral blood flow in the hippocampal area of the repeated cerebral ischemia model using laser Doppler flowmetry. The 14-day pre-ischemic treatment with KGK increased the cerebral blood flow during reperfusion. These results suggest that a 21-day pre- and post-ischemic treatment with KGK can protect against brain damage caused by cerebral ischemia by increasing the cerebral blood flow in the hippocampal area.",
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AU - Kaneko, Tomohiro

AU - Tanaka, Yurika

AU - Manome, Naomi

AU - Irie, Keiichi

AU - Takata, Jirou

AU - Egashira, Nobuaki

AU - Oishi, Ryozo

AU - Okamoto, Takuya

AU - Sei, Yasuo

AU - Yokozawa, Takako

AU - Mishima, Kenichi

AU - Iwasaki, Katsunori

AU - Fujiwara, Michihiro

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Y1 - 2009/6/22

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