New approach for investigating neuropathic allodynia by optogenetics

研究成果: ジャーナルへの寄稿記事

抄録

Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodynia have not been fully determined. Recent technological advances have made it possible to achieve subpopulation-specific ablation, silencing or stimulation, and to dissect and elucidate complex neuronal circuitry. Recent studies using an optogenetic approach have shown that activation of LTMRs, including Aβ fibers that genetically express channelrhodopsin-2, by illuminating blue light to the skin elicit morphine-resistant withdrawal behaviors after nerve damage. Whole-cell recording has revealed that optical Aβ stimulation after nerve injury causes excitation of lamina I dorsal horn neurons, which are normally silent by this stimulation. Moreover, Aβ stimulation after nerve injury results in activation of central amygdaloid neurons and produces aversive behaviors. In summary, these findings indicate that optogenetics is a powerful approach for investigating LTMR-derived pain (resembling mechanical allodynia) with sensory and emotional features after nerve injury and for discovering novel and effective drugs to treat neuropathic pain.

元の言語英語
ページ(範囲)S53-S58
ジャーナルPain
160
DOI
出版物ステータス出版済み - 5 1 2019

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Optogenetics
Mechanoreceptors
Hyperalgesia
Myelinated Nerve Fibers
Neuralgia
Wounds and Injuries
Posterior Horn Cells
Pain
Patch-Clamp Techniques
Morphine
Neurons
Light
Skin
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

これを引用

New approach for investigating neuropathic allodynia by optogenetics. / Makoto, Tsuda.

:: Pain, 巻 160, 01.05.2019, p. S53-S58.

研究成果: ジャーナルへの寄稿記事

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